CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1)

Lastly, epiregulin, a known growth factor upregulated in premalignant stages of lung cancer specifically during tumor-promoting inflammation, was also significantly elevated above control in response to 5 μg/mL WSP. These early results support a link between inflammation and gap junctions and provide a critical new mechanistic understanding of how WSP contribute to early adverse events in a lung cell line along with the potential to prevent these adverse outcomes with interventions such as parthenolide.

ChIP-PCR verified that NRF2 could directly bind to two specific regions (460-565 bp and 1488-1623 bp) within the SLC7A11 promoter to regulate amino acid metabolism. Collectively, our findings demonstrate that NRF2-regulated SLC7A11-mediated amino acid metabolic reprogramming plays a pivotal role in BaP-induced cellular malignant transformation.

The senolytic activity of thioQ(OAc)4 with four acetylated hydroxy groups against cisplatin-induced senescent melanoma cells was also revealed in selected experimental settings. We suggest that the use of novel thioquercetin-based derivatives along with HSP90 inhibitors should be further validated in vivo and considered for the design of more effective antimelanoma strategies in the future.

Notably, FOXA1 and RAB25 are strongly implicated in breast cancer biology, and FOXA1 has been directly linked to the aryl hydrocarbon receptor (AHR), the main regulator of CYP1A1. These results position CEU-938 as a strong precision-therapy candidate that combines target selectivity, a favorable toxicity profile, and biomarker-enabled patient stratification, with potential clinical benefit in ER+ and HER2+ enriched tumors, as well as a subset of TNBC.

Critically, ALI organotypic cultures derived from BaP-exposed cells exhibited histological dysplasia, nuclear pleomorphism, and disrupted apical-basal polarity. These findings mechanistically link chronic BaP exposure to an initiation-like preneoplastic state and establish a validated 2D/3D multi-omics platform for PAH-driven lung carcinogenesis research.

Direct quantification of POPs in gastric tissue revealed selective accumulation patterns associated with stomach cancer. While systemic distribution and genetic variability may influence susceptibility, tissue-level POP differences represented the most consistent findings. Larger prospective studies are warranted to clarify temporal and mechanistic relationships.

Moreover, the metabolic differences between DBA and the analogous 7H-dibenzo[c,g]carbazole originate from the distinct nitrogen characteristics. This study elucidates the metabolic activation of DBA in human CYP1A1 and improves the theoretical framework for heterocyclic aromatic compounds metabolism.

The tumor-promoting effects of PVC-MPs were further validated in primary human endometrial cancer cells and mouse models (including both cell line-derived xenograft and patient-derived xenograft), substantially strengthening the robustness and translational relevance of our study. Collectively, these findings establish PVC-MPs as an environmental risk factor for EC and identify AHR/CYP1A1 signaling pathway as potential therapeutic targets to mitigate the adverse effects of microplastic exposure, developing preventive interventions in exposed populations against EC (Graphic abstract).

In silico analysis with molecular docking also predicted SFN interactions with selected proteins involved in drug detoxification and cell death that warrants further investigation. We postulate that SFN may have senotherapeutic potential, especially against apoptosis resistant chemotherapy-induced senescent normal and breast cancer cells.

The strong correspondence between histopathological and transcriptional biomarkers demonstrates that this species is highly sensitive to styrene toxicity and suitable for ecotoxicological monitoring. Findings highlight the need for environmental surveillance of industrial pollutants in tropical freshwater systems.

AB129 elevated CYP1A1 and CYP1A2 gene expression but increased only EROD activity. RBBR upregulated CYP1A2 and CYP2B6 gene expression, but did not affect the activity of any measured cytochrome assays.

The miR-18a-5p/CYP1A1/PPAR axis is a novel pathway that could be targeted for AFL treatment.