CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1)

The strong correspondence between histopathological and transcriptional biomarkers demonstrates that this species is highly sensitive to styrene toxicity and suitable for ecotoxicological monitoring. Findings highlight the need for environmental surveillance of industrial pollutants in tropical freshwater systems.

AB129 elevated CYP1A1 and CYP1A2 gene expression but increased only EROD activity. RBBR upregulated CYP1A2 and CYP2B6 gene expression, but did not affect the activity of any measured cytochrome assays.

The miR-18a-5p/CYP1A1/PPAR axis is a novel pathway that could be targeted for AFL treatment.

Additionally, jejunal expression of G-protein coupled receptor 41 (GPR41) and Claudin 1 was markedly higher in the weaned piglets of NaB group than those in control group (P < 0.05). Collectively, these findings suggest that NaB supplementation during mid-to-late gestation could improve placental function in sows, which is associated with enhanced antioxidant capacity, attenuated inflammation, and improved intestinal development in the offspring.

Key apoptosis-associated genes, including ALDH3A1, CYP1A1, NOS3, MT1X, and CES1, were further validated by RT-qPCR. These findings suggest CNDCM as a potential candidate for breast cancer therapy.

Compared with parental cells, these resistant cells exhibited reduced sensitivity to paclitaxel, adriamycin, and eribulin in the viability assays. These results suggest that ZSTK3744 combines robust cell growth-inhibitory activity with a favorable safety profile. In conclusion, ZSTK3744 is a promising candidate for overcoming chemotherapy resistance in TNBC, addressing the urgent need for more effective treatment options for this aggressive cancer subtype.

Pathway enrichment analyses highlighted oxidative stress, IL-17, NF-κB, and immune checkpoint signaling. Together, biomass haze-derived PM2.5 from Northern Thailand drives genotype-dependent oxidative stress and transcriptional remodeling in NSCLC cells.

PAE200-Cd significantly increased the expression of cytochrome P450 family 1 subfamily A (CYP1A1) and downregulated the expression of metallothionein (MT) and cysteine-aspartic proteases-9 (Caspase-9). The optimal PAE dose for counteracting waterborne Cd-induced growth impairment and hepatic oxidative stress was 173.37-173.90 mg/kg for largemouth bass.

The method exhibited acceptable extraction recovery, matrix effects, and stability, confirming compliance with regulatory standards. The validated method was successfully applied to characterize serum steroid metabolic profiles in both N-methyl-N-nitrosourea-induced breast cancer and ovariectomized rat models, revealing alterations in estrogen 2-hydroxylation and pregnenolone 21-hydroxylation pathways mediated by key steroidogenic enzymes, including CYP1A1/CYP1B1 and potentially CYP21A2-independent mechanisms, providing robust support for preclinical research on steroid-related diseases.

Importantly, further analysis revealed that the differentiation process promoted by aesculetin was associated with the activation of the STAT3 and STAT5 signaling pathways. Collectively, these findings underscore the pivotal role of aesculetin in promoting the hepatic differentiation of hBM-MSCs and demonstrate its potential as a key component for regenerative medicine applications in liver tissue engineering or stem cell-based therapies.

Western blot analysis further confirmed that KKP can effectively downregulate the expression of cytochrome P450 family 1 subfamily A member 1(CYP1A1), nitric oxide synthase 2(NOS2) and monoamine oxidase A(MAOA), arachidonate 5-lipoxygenase(ALOX5), prostaglandin-endoperoxide synthase 1(PTGS1), and p38 mitogen-activated protein kinase(p38 MAPK). In summary, the study reveals the clinical potential of KKP in the treatment of PIC and confirms that KKP alleviates inflammation and improves cough symptoms through multi-target and multi-pathway regulation, with the mechanism of action likely related to MAPK signaling pathway, arginine metabolism, and other inflammation-related pathways.