cyclosporine

CA9 is enriched in hypoxic MES-like GSCs in rGBM and promotes an ANXA1-dependent paracrine program that supports immunosuppressive macrophage polarization. These findings identify a CA9-ANXA1-FPR1-associated neuroimmune crosstalk axis linking hypoxic stem-like tumor states to myeloid remodeling in recurrent GBM, with ANXA1 functioning as a contributory paracrine mediator rather than a sole effector of CA9-driven immunosuppression.

The conjunctival lesion regressed with topical corticosteroid and cyclosporine therapy...Recent or resolving systemic EBV infection may be temporally associated with conjunctival reactive lymphoid hyperplasia mimicking preseptal cellulitis. Delayed CIs may represent an additional feature of this inflammatory spectrum, although causality remains unproven without lesion-specific EBV detection.

P4, N=30, Not yet recruiting, Peking University People's Hospital | N=118 --> 30

CADM is a serious, complex disease with a distinct clinical and serological profile, requiring further conceptual refinement and multicenter studies to better characterize this DM phenotype.

In 2022, acitretin was commenced and uptitrated to 25 mg once daily...Other immunosuppressive agents, such as methotrexate, cyclosporine, and azathioprine, have been described in the literature with varying efficacy...Naltrexone is postulated to work due to its analgesic and anti-inflammatory effects. It is a well-tolerated treatment for severe HHD that has drastically improved both our patient's skin and his quality of life.

The patient responded to ciclosporin therapy with gradual haematological improvement and became transfusion-independent within 6 months. This case highlights the importance of molecular profiling in T-LGLL presentations and expands the known mutational spectrum of STAT3 It also raises the possibility that non-SH2 (Src homology 2) domain STAT3 mutations may contribute to disease pathogenesis and influence treatment response in T-LGLL.

P4, N=10, Not yet recruiting, University of California, San Francisco | Initiation date: Jan 2026 --> Aug 2026

P2, N=30, Completed, City of Hope Medical Center | Active, not recruiting --> Completed

P2, N=260, Active, not recruiting, City of Hope Medical Center | Trial completion date: Apr 2026 --> Mar 2027

This review provides a systematic analysis of the clinical, biological, and histological characteristics of EF, its associated triggers, and therapeutic strategies based on a comprehensive review of reported cases. We found that poor prognostic factors include diagnostic delay (>6 months), trunk involvement, early-onset disease (<12 years), and morphea-like skin lesions.

Among patients with psoriasis and DM, APR was associated with a lower incidence of DM-AEs, whereas cyclosporine and acitretin were associated with higher incidences compared with MTX.

P2, N=400, Recruiting, University of Birmingham | Trial completion date: Jan 2026 --> Aug 2027 | Trial primary completion date: Jan 2026 --> Aug 2027