^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    cyclosporine

    Company:
    Generic mfg.
    Drug class:
    Calcineurin inhibitor
    Related drugs:
    7d
    Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD (clinicaltrials.gov)
    P4, N=30, Not yet recruiting, Peking University People's Hospital | N=118 --> 30
    Enrollment change
    |
    prednisone • cyclosporine
    9d
    Clinically Amyopathic Dermatomyositis: Epidemiology, Clinical Presentation, Pathophysiology, Treatment, and Prognosis: A Systematic Review. (PubMed, Rheumatol Ther)
    CADM is a serious, complex disease with a distinct clinical and serological profile, requiring further conceptual refinement and multicenter studies to better characterize this DM phenotype.
    Review • Journal
    |
    IFIH1 (Interferon Induced With Helicase C Domain 1) • CRP (C-reactive protein)
    |
    Rituxan (rituximab) • cyclophosphamide • cyclosporine
    17d
    The Use of Naltrexone to Successfully Treat Severe Hailey-Hailey Disease. (PubMed, Cureus)
    In 2022, acitretin was commenced and uptitrated to 25 mg once daily...Other immunosuppressive agents, such as methotrexate, cyclosporine, and azathioprine, have been described in the literature with varying efficacy...Naltrexone is postulated to work due to its analgesic and anti-inflammatory effects. It is a well-tolerated treatment for severe HHD that has drastically improved both our patient's skin and his quality of life.
    Journal
    |
    IL6 (Interleukin 6) • TLR4 (Toll Like Receptor 4)
    |
    methotrexate • cyclosporine • naltrexone
    20d
    T-cell large granular lymphocyte leukaemia with pure red cell aplasia harbouring a somatic STAT3 P715L mutation. (PubMed, BMJ Case Rep)
    The patient responded to ciclosporin therapy with gradual haematological improvement and became transfusion-independent within 6 months. This case highlights the importance of molecular profiling in T-LGLL presentations and expands the known mutational spectrum of STAT3 It also raises the possibility that non-SH2 (Src homology 2) domain STAT3 mutations may contribute to disease pathogenesis and influence treatment response in T-LGLL.
    Journal
    |
    CD8 (cluster of differentiation 8) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    |
    STAT3 mutation
    |
    cyclosporine
    22d
    Utilization of a Microdevice for Psoriasis and Atopic Dermatitis (clinicaltrials.gov)
    P4, N=10, Not yet recruiting, University of California, San Francisco | Initiation date: Jan 2026 --> Aug 2026
    Trial initiation date
    |
    5-fluorouracil • Jakafi (ruxolitinib) • hydroxychloroquine • cyclosporine • roflumilast • tofacitinib • Cosentyx (secukinumab) • Dupixent (dupilumab) • Ilumya (tildrakizumab-asmn) • chloroquine phosphate
    22d
    Busulfan, Etoposide, and Total-Body Irradiation in Treating Patients Undergoing Donor Stem Cell or Bone Marrow Transplant for Advanced Hematologic Cancer (clinicaltrials.gov)
    P2, N=30, Completed, City of Hope Medical Center | Active, not recruiting --> Completed
    Trial completion
    |
    Chr del(5q)
    |
    etoposide IV • busulfan • cyclosporine
    23d
    Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders (clinicaltrials.gov)
    P2, N=260, Active, not recruiting, City of Hope Medical Center | Trial completion date: Apr 2026 --> Mar 2027
    Trial completion date
    |
    HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B)
    |
    cyclophosphamide • etoposide IV • sirolimus • melphalan • fludarabine IV • busulfan • cyclosporine
    28d
    Eosinophilic fasciitis: a comprehensive systematic review of clinical, histologic, and therapeutic perspectives. (PubMed, Ital J Dermatol Venerol)
    This review provides a systematic analysis of the clinical, biological, and histological characteristics of EF, its associated triggers, and therapeutic strategies based on a comprehensive review of reported cases. We found that poor prognostic factors include diagnostic delay (>6 months), trunk involvement, early-onset disease (<12 years), and morphea-like skin lesions.
    Journal
    |
    IL5 (Interleukin 5)
    |
    Rituxan (rituximab) • methotrexate • hydroxychloroquine • cyclosporine
    1m
    Safety Profile of Systemic Therapy for the Management of Psoriasis in Patients With Diabetes Mellitus: Data From the BIOBADADERM Prospective Cohort. (PubMed, Actas Dermosifiliogr)
    Among patients with psoriasis and DM, APR was associated with a lower incidence of DM-AEs, whereas cyclosporine and acitretin were associated with higher incidences compared with MTX.
    Journal
    |
    IL17A (Interleukin 17A) • IL23A (Interleukin 23 Subunit Alpha)
    |
    methotrexate • cyclosporine
    2ms
    Methods of T Cell Depletion Trial (MoTD) (clinicaltrials.gov)
    P2, N=400, Recruiting, University of Birmingham | Trial completion date: Jan 2026 --> Aug 2027 | Trial primary completion date: Jan 2026 --> Aug 2027
    Trial completion date • Trial primary completion date
    |
    cyclophosphamide • sirolimus • cyclosporine • methylprednisolone sodium succinate
    2ms
    Cord Blood Transplantation in Children and Young Adults With Blood Cancer (clinicaltrials.gov)
    P2, N=71, Recruiting, Memorial Sloan Kettering Cancer Center
    New P2 trial
    |
    TP53 (Tumor protein P53) • KMT2A (Lysine Methyltransferase 2A)
    |
    cyclophosphamide • clofarabine • fludarabine IV • thiotepa • busulfan • cyclosporine
    2ms
    Drug-Drug Interactions of JMKX003142 in Healthy Participants (clinicaltrials.gov)
    P1, N=112, Not yet recruiting, Jemincare
    New P1 trial
    |
    cyclosporine • efavirenz • omeprazole