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    DRUG:

    cyclosporine

    Company:
    Generic mfg.
    Drug class:
    Calcineurin inhibitor
    Related drugs:
    3d
    Primary Cutaneous B-Cell Lymphoma Imitating Pyoderma Gangrenosum: A Rare and Complex Diagnostic Challenge. (PubMed, J Clin Med)
    An 85-year-old male presented with multiple rapidly progressive, painful, ulcerative lesions, initially misdiagnosed as PG and treated with oral cyclosporine with no clinical response... The case documents an exceptionally rare cutaneous presentation of A-DLBCL, expanding the extremely limited literature on this enigmatic entity. Furthermore, it underscores the fundamental role of early skin biopsy in the differential diagnosis of non-specific ulcerative lesions, which is critical for ensuring appropriate treatment administration within the therapeutic window in cases of malignancy.
    Journal
    |
    CD20 (Membrane Spanning 4-Domains A1) • TNFRSF8 (TNF Receptor Superfamily Member 8) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C)
    |
    TNFRSF8 positive
    |
    cyclosporine
    5d
    A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia (clinicaltrials.gov)
    P2, N=40, Completed, Institute of Hematology & Blood Diseases Hospital, China | Unknown status --> Completed
    Trial completion
    |
    cyclosporine • levamisole
    5d
    SZ-GVHD 06: Sitagliptin for Prevention of aGVHD After Alternative Donor Transplation (clinicaltrials.gov)
    P3, N=190, Completed, The First Affiliated Hospital of Soochow University | Recruiting --> Completed | Trial completion date: Feb 2024 --> Jun 2025
    Trial completion • Trial completion date
    |
    cyclosporine
    10d
    Pulmonary alveolar proteinosis developing during tofacitinib treatment for anti-MDA5 antibody-positive dermatomyositis-associated interstitial lung disease: a case report and review of the literature. (PubMed, Immunol Med)
    A 74-year-old Japanese woman with rapidly progressive DM-associated ILD was treated with high-dose glucocorticoids, intravenous cyclophosphamide, and cyclosporine, followed by tofacitinib due to an insufficient response. Discontinuation of tofacitinib alone resulted in rapid clinical and radiological improvement. This case highlights PAP as a rare, potentially reversible complication during JAK inhibitor therapy in anti-MDA5 antibody-positive DM-associated ILD and underscores the importance of considering PAP when elevated KL-6 levels and radiological abnormalities occur despite only mild respiratory symptoms.
    Journal
    |
    IFIH1 (Interferon Induced With Helicase C Domain 1)
    |
    cyclophosphamide • cyclosporine • tofacitinib
    14d
    COMPARE: Cyclosporine Or Methotrexate for Pediatric Alopecia Areata: Routine Clinical Care Effectiveness Study (clinicaltrials.gov)
    P4, N=50, Recruiting, Erasmus Medical Center
    New P4 trial
    |
    cyclosporine
    16d
    Observation on the efficacy of 0.05% cyclosporine in treating dry eye syndrome caused by thyroid-associated ophthalmopathy (ChiCTR2500115401)
    P=N/A, N=66, Recruiting, Northern Theater Command General Hospital of the Chinese People's Liberation Army; Northern Theater Command General Hospital of the Chinese People's L
    New trial
    |
    cyclosporine
    16d
    Comparison of the application effect of cyclosporine combined with sufentanil versus cyclosporine combined with remifentanil in painless gastroscopy in elderly patients (ChiCTR2500114516)
    P=N/A, N=174, Not yet recruiting, Hohhot First Hospital; Hohhot First Hospital
    New trial
    |
    cyclosporine • Sufenta (sufentanil)
    16d
    The Effects of Propofol and Cipropofol on Perioperative Neurocognitive Disorders in Elderly Patients (ChiCTR2600117749)
    P4, N=134, Not yet recruiting, Inner Mongolia Medical University Affiliated Hospital; Inner Mongolia Medical University Affiliated Hospital
    New P4 trial
    |
    cyclosporine
    16d
    Efficacy and Safety of Herombopag Ethanolamine Tablets in Combination with Cyclosporine and Androgen for the Treatment of Transfusion-Dependent Non-Severe Aplastic Anemia (TD-NSAA) Patients—A Single-Arm, Prospective, Multicenter Phase II Clinical Study (ChiCTR2500114419)
    P4, N=42, Recruiting, West China Hospital of Sichuan University; West China Hospital of Sichuan University
    New P4 trial
    |
    cyclosporine
    18d
    CsA/Met: Combined Use of Cyclosporine and Metformin in Treatment of Psoriasis vs Cyclosporine Alone (clinicaltrials.gov)
    P1, N=32, Completed, Cairo University
    New P1 trial
    |
    metformin • cyclosporine
    20d
    Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation (clinicaltrials.gov)
    P1/2, N=43, Active, not recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Oct 2026 --> Apr 2026 | Trial primary completion date: Oct 2025 --> Jul 2025
    Trial completion date • Trial primary completion date
    |
    HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-C (Major Histocompatibility Complex, Class I, C)
    |
    cyclophosphamide • Zolinza (vorinostat) • cyclosporine
    27d
    Utilization of a Microdevice for Psoriasis and Atopic Dermatitis (clinicaltrials.gov)
    P4, N=10, Not yet recruiting, University of California, San Francisco
    New P4 trial
    |
    5-fluorouracil • Jakafi (ruxolitinib) • hydroxychloroquine • cyclosporine • roflumilast • tofacitinib • Cosentyx (secukinumab) • Dupixent (dupilumab) • Ilumya (tildrakizumab-asmn) • chloroquine phosphate