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    BIOMARKER:

    CXCR4 overexpression + RIF1 overexpression

    i
    Other names: CXCR4, CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R, Chemokine (C-X-C motif) receptor 4, RIF1, Replication Timing Regulatory Factor 1, Rap1-Interacting Factor 1 Homolog, Telomere-Associated Protein RIF1, FLJ12870, FLJ10599, RAP1 Interacting Factor Homolog (Yeast), RAP1 Interacting Factor Homolog
    Entrez ID:
    7852; 55183
    Related biomarkers:
    Expression
    Mutation
    2years
    CXCR4 and RIF1 overexpression induces resistance of epithelial ovarian cancer to cisplatin-based chemotherapy. (PubMed, J Cancer Res Ther)
    The only prognostic associated with overall survival was CXCR4. Our study showed that CXCR4 and RIF1expression levels are not associated only with poor prognostic features of epithelial ovarian cancer but also with its chemoresistance to cisplatin, and consequently, with worse overall survival and progression free survival.
    Journal
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • RIF1 (Replication Timing Regulatory Factor 1)
    |
    CXCR4 overexpression + RIF1 overexpression
    |
    cisplatin