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    BIOMARKER:

    CXCL8 overexpression

    i
    Other names: CXCL8, 3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1, Chemokine (C-X-C motif) ligand 8
    Entrez ID:
    3576
    Related biomarkers:
    Expression
    Others
    2ms
    CXCL8 generates an immunosuppressive microenvironment in colorectal cancer through induction of M2 macrophage infiltration and inhibition of CD8+ T cell infiltration (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    However, overexpression of CXCL8 in CRC cells did not affect the cytotoxicity of CD8+ T cells in vitro. Conclusion CXCL8-overexpressing CRC cells promoted the infiltration of M2 macrophages and inhibited CD8+ T cell infiltration to generate an immunosuppressive microenvironment in CRC.
    Journal
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    CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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    CXCL8 overexpression