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    BIOMARKER:

    CXCL8 overexpression

    i
    Other names: CXCL8, 3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1, Chemokine (C-X-C motif) ligand 8
    Entrez ID:
    3576
    Related biomarkers:
    Expression
    Others
    5ms
    CXCL8 is essential for cervical cancer cell acquired radioresistance and acts as a promising therapeutic target in cervical cancer. (PubMed, Sci Rep)
    GEPIA2 and immunohistochemistry revealed CXCL8 overexpression in tumors. Functional studies demonstrated CXCL8 knockdown sensitized resistant cells to radiation, while exogenous CXCL8 induced resistance in parental lines.
    Journal
    |
    CXCL8 (Chemokine (C-X-C motif) ligand 8) • CA9 (Carbonic anhydrase 9) • MMP1 (Matrix metallopeptidase 1) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    |
    CXCL8 overexpression
    11ms
    Investigating the Role of Quercetin, an Active Ingredient in Bazhen Decoction, in Targeting CXCL8 to Inhibit Macrophage M2 Polarization and Reshape the Immunological Microenvironment of Colorectal Cancer. (PubMed, Chem Biol Drug Des)
    Quercetin, the active component in Bazhen Decoction that is known for anti-CRC effects, targets and inhibits CXCL8 to impede the malignant behaviors and the M2 polarization of macrophages. Thus, Quercetin may be utilized as an immunomodulatory agent in CRC treatment.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • CASP3 (Caspase 3)
    |
    CXCL8 overexpression
    1year
    CXCL8 generates an immunosuppressive microenvironment in colorectal cancer through induction of M2 macrophage infiltration and inhibition of CD8+ T cell infiltration (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    However, overexpression of CXCL8 in CRC cells did not affect the cytotoxicity of CD8+ T cells in vitro. Conclusion CXCL8-overexpressing CRC cells promoted the infiltration of M2 macrophages and inhibited CD8+ T cell infiltration to generate an immunosuppressive microenvironment in CRC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
    |
    CXCL8 overexpression