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    BIOMARKER:

    CXCL12-L

    i
    Other names: CXCL12, C-X-C Motif Chemokine Ligand 12, Stromal Cell-Derived Factor 1, PBSF, Pre-B Cell Growth-Stimulating Factor, Chemokine (C-X-C Motif) Ligand 12, Intercrine Reduced In Hepatomas, SCYB12, TPAR1, SDF1, IRH, C-X-C Motif Chemokine 12, CXCL12, SDF-1a, SDF-1b, TLSF-A, TLSF-B, HSDF-1, SDF1A, SDF1B, SDF-1, TLSF, HIRH
    Entrez ID:
    6387
    Related biomarkers:
    Expression
    Mutation
    Others
    2ms
    CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization. (PubMed, bioRxiv)
    The CXCL12-LD partial agonist effectively mobilized stem cells into the bloodstream in mice suggesting a potential role for their use in targeting CXCR4. Together, our results suggest that enhanced internalization by CXCL12-LD partial agonist signaling can avoid pharmacodynamic tolerance and may identify new avenues to better target GPCRs.
    Journal
    |
    CXCL12 (C-X-C Motif Chemokine Ligand 12)
    |
    CXCL12-L • CXCR4 positive
    6ms
    The effect of CXCL12 on survival outcomes of patients with viral hepatitis-associated hepatocellular carcinoma after hepatectomy. (PubMed, Heliyon)
    Our findings suggest that, when assessing the prognostic significance of CXCL12 in HCC, it is essential to consider the expression level of its receptor. Nevertheless, CXCL12 can potentially serve as a promising prognostic marker for HCC.
    Journal
    |
    CXCL12 (C-X-C Motif Chemokine Ligand 12) • ACKR3 (Atypical Chemokine Receptor 3)
    |
    CXCL12 expression • CXCL12-L • CXCR4 expression