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    GENE:

    CXADR (CXADR Ig-Like Cell Adhesion Molecule)

    i
    Other names: CXADR, CXADR Ig-Like Cell Adhesion Molecule, CAR, Coxsackie Virus And Adenovirus Receptor, Coxsackievirus And Adenovirus Receptor, Coxsackievirus B-Adenovirus Receptor, CVB3-Binding Protein, HCVADR, HCAR, 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein, CXADR, Ig-Like Cell Adhesion Molecule, CAR4/6
    Associations

    News

    Trials
    5ms
    Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer. (PubMed, Int J Med Sci)
    Furthermore, CEACAM5, KLK1, and CD14 correspond to existing drugs. These proteins may deepen our comprehension of the etiology and could serve as appealing novel biomarkers and drug targets for NSCLC management.
    Clinical • Journal
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    CEACAM5 (CEA Cell Adhesion Molecule 5) • CD14 (CD14 Molecule) • CDH17 (Cadherin 17) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
    10ms
    Identification of Novel Protein Biomarkers for Intrahepatic Cholangiocarcinoma by Integrating Human Plasma Proteome with Genome. (PubMed, J Gastrointest Cancer)
    This study represents the first Proteome-MR analysis of ICC, revealing its complex genetic architecture and identifying five novel blood proteins with potential causal links to the disease. Through proteome-MR analysis, scRNA-seq analysis, and diagnostic-prognostic evaluation using TCGA and GTEx databases, these proteins were assessed as promising therapeutic and diagnostic targets. The findings provide a theoretical foundation for future ICC treatment strategies.
    Journal
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    CD163 (CD163 Molecule) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
    1year
    Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells. (PubMed, Int J Mol Sci)
    In these lines, the main viral receptor genes, including PVR, CXADR, CD55, ITGA2, SCARB2, ICAM1, and FCGRT, were knocked out using the CRISPR/Cas9 system. The panel of lines was validated on twelve different Enteroviruses types, providing a basis for studying the molecular mechanisms of enterovirus entry into cells, and for developing new therapeutic strains.
    Preclinical • Journal
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    ICAM1 (Intercellular adhesion molecule 1) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • CD55 (CD55 Molecule) • CXADR (CXADR Ig-Like Cell Adhesion Molecule) • FCGRT (Fc Gamma Receptor And Transporter) • ITGA2 (Integrin Subunit Alpha 2)
    over1year
    Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma. (PubMed, Pathol Res Pract)
    No prognostic significance of the expression of DSG-2, CXADR or CD46 in HNSCC was seen. DSG-2, CXADR and CD46 are expressed in HNSCC, so that optimization of oncotherapy with adenoviral vectors appears promising. Due to the significantly increased expression of DSG-2 and CXADR in advanced OPSCC tumors, there is potential for optimizing oncotherapy here in particular.
    Journal
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    CXADR (CXADR Ig-Like Cell Adhesion Molecule) • CD46 (CD46 Molecule)
    over1year
    TAZ DOWNREGULATES ANXA1 EXPRESSION TO MODULATE MYELOMA CELL INTERACTION WITH BONE MARROW MESENCHYMAL STROMAL CELLS. (PubMed, Exp Hematol)
    Our data provide new insights into the understanding of the role of TAZ in the intercellular communication signals between myeloma cells and BM-MSCs. Our findings also suggest that ANXA1 represents a putative cell adhesion target to attenuate BM-MSC driven, tumour-promoting interaction with myeloma cells.
    Journal • Stroma
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    NCAM1 (Neural cell adhesion molecule 1) • ANXA1 (Annexin A1) • ADGRG7 (Adhesion G Protein-Coupled Receptor G7) • CXADR (CXADR Ig-Like Cell Adhesion Molecule) • TAFAZZIN (Tafazzin)
    almost2years
    JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment. (PubMed, In Vitro Cell Dev Biol Anim)
    CXADR can inhibit the proliferation of cancer cells and promote the apoptosis. JAML agonist can effectively treat colorectal cancer by regulating CD8+ T cells.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
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    CD8 overexpression • CD8 expression • HAVCR2 expression • JAML overexpression
    almost2years
    JAML promotes the antitumor role of tumor-resident CD8+ T cells by facilitating their innate-like function in human lung cancer. (PubMed, Cancer Lett)
    Our study reveals an intrinsic bias of CD8+TRMs for receiving the tumor-derived costimulatory signal in the TME, which sustains their innate-like function and antitumor role. These findings will shed more light on the biology of CD8+TRMs and aid in the development of potential targeted treatment strategies for NSCLC.
    Journal
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    CD8 (cluster of differentiation 8) • JAML (Junction Adhesion Molecule Like) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
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    CD8 expression
    almost2years
    Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche. (PubMed, Acta Neuropathol Commun)
    Importantly, we highlight the limited correlation between transcriptomics and proteomics, emphasizing the critical role of membrane protein enrichment strategies and quantitative mass spectrometry. Our findings provide a comprehensive understanding of the surface-endocytome and its remodeling by hypoxia in GBM as a resource for exploration of targets for immunotherapeutic approaches in GBM.
    Journal • IO biomarker
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    CD81 (CD81 Molecule) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
    over2years
    CAR virus receptor mediates erythroid differentiation and migration and is downregulated in MDS. (PubMed, Leukemia)
    Together, CAR is a functionally relevant marker that is down-regulated on EP in MDS and is of prognostic significance. Decreased CAR expression may contribute to the maturation defect and altered migration of EP and thus their pathologic accumulation in the BM in MDS.
    Journal
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    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD36 (thrombospondin receptor) • TFRC • ENG (Endoglin) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
    over2years
    Multi-omic Characterization and Molecular Profiling of NUT Carcinoma (AMP 2023)
    NRG1 fusion events are infrequently observed in ovarian, fallopian tube, and primary peritoneal carcinomas, and include a diversity of previously unknown partner genes. However, they may carry diagnostic significance in the context of borderline/low-grade serous tumors and have important therapeutic implications with the emergence of new targeted treatments.
    Tumor mutational burden • BRCA Biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • BRCA1 (Breast cancer 1, early onset) • PTEN (Phosphatase and tensin homolog) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • FGFR3 (Fibroblast growth factor receptor 3) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • ARID1A (AT-rich interaction domain 1A) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • NRG1 (Neuregulin 1) • KMT2D (Lysine Methyltransferase 2D) • CDK12 (Cyclin dependent kinase 12) • MUC16 (Mucin 16, Cell Surface Associated) • NOTCH2 (Notch 2) • CHEK2 (Checkpoint kinase 2) • ADAM9 (ADAM Metallopeptidase Domain 9) • EP300 (E1A binding protein p300) • RAD51D (RAD51 paralog D) • WRN (WRN RecQ Like Helicase) • IR (Insulin receptor) • FANCE (FA Complementation Group E) • JAG1 (Jagged Canonical Notch Ligand 1) • CXADR (CXADR Ig-Like Cell Adhesion Molecule) • FANCC (FA Complementation Group C) • TMEM65 (Transmembrane Protein 65) • TNFRSF12A (TNF Receptor Superfamily Member 12A)
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    NRG1 fusion • NRG1 fusion
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    MI Tumor Seek™
    over2years
    CXADR-Like Membrane Protein regulates colonic epithelial cell proliferation and prevents tumor growth. (PubMed, Gastroenterology)
    These results reveal novel insights into CLMP function in the colonic epithelium, highlighting an important role in regulating IEC proliferation, suggesting tumor suppressive function in colon cancer.
    Journal
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    CXADR (CXADR Ig-Like Cell Adhesion Molecule)
    over2years
    Phosphoproteomics of patient-derived xenographs identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer. (PubMed, Sci Transl Med)
    Inhibition of these hyperactive kinases, alone or in combination with cetuximab, resulted in growth inhibition of ex vivo PDX-derived organoids and in vivo PDXs. Together, these findings highlight the potential value of phosphoproteomics to improve our understanding of anti-EGFR treatment and response prediction in mCRC and bring to the forefront alternative drug targets in cetuximab-resistant tumors.
    Journal
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    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • CLDN1 (Claudin 1) • CXADR (CXADR Ig-Like Cell Adhesion Molecule)
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    Erbitux (cetuximab)