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    GENE:

    CUL9 (Cullin 9)

    i
    Other names: CUL9, Cullin 9, H7AP1, PARC, P53-Associated Parkin-Like Cytoplasmic Protein, KIAA0708, Parkin-Like Cytoplasmic P53 Binding Protein, UbcH7-Associated Protein 1, Cullin-9, CUL-9
    Associations

    News

    Trials
    4ms
    Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma. (PubMed, Front Mol Biosci)
    WSB2 and COMMD2 jointly predicted that hsa-miR-185-5p, hsa-miR-4644 and hsa-miR-4306 were the common microRNAs (miRNAs) and regulatory networks. This study successfully established a neddylation-associated prognostic risk model for LSCC and revealed that COMMD2, WSB2, and CUL9 could act as new therapeutic targets, which might provide valuable information for the research and treatment of LSCC.
    Journal
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    WSB2 (WD Repeat And SOCS Box Containing 2) • miR-185 (MicroRNA 185) • MIR4306 (MicroRNA 4306) • CUL9 (Cullin 9) • MIR4644 (MicroRNA 4644)
    8ms
    Analysis of cullin family genes in rectal adenocarcinoma: expression, prognostic significance, and therapeutic implications. (PubMed, Am J Transl Res)
    This study provides novel insight into the role of cullin genes in READ, suggesting that CUL2 and CUL7 may be biomarkers and therapeutic targets. Further research is warranted to explore their underlying mechanisms and clinical applications in READ management.
    Journal
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    CUL4A (Cullin 4A) • CUL1 (Cullin 1) • CUL7 (Cullin 7) • CUL2 (Cullin 2) • CUL4B (Cullin 4B) • CUL9 (Cullin 9)
    over1year
    Comprehensive analysis of the Cullin family of genes reveals that CUL7 and CUL9 are the significant prognostic biomarkers in colorectal cancer. (PubMed, Am J Transl Res)
    Overall, these multifaceted analyses elucidated the intricate involvement of Cullin family genes in CRC pathogenesis and provided valuable insights for future diagnostic and therapeutic endeavors in CRC management.
    Journal
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    CUL4A (Cullin 4A) • CUL1 (Cullin 1) • CUL7 (Cullin 7) • CUL2 (Cullin 2) • CUL4B (Cullin 4B) • CUL9 (Cullin 9)
    almost2years
    Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. (PubMed, Nat Struct Mol Biol)
    Our data show CUL9 as unique among RBX1-bound cullins in dependence on the metazoan-specific UBE2F neddylation enzyme, while the RBR domain protects it from deneddylation. Substrates are recruited to various upstream domains, while ubiquitylation relies on both CUL9's neddylated cullin and RBR domains achieving self-assembled and chimeric cullin-RING/RBR E3 ligase activity.
    Journal
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    TP53 (Tumor protein P53) • CUL9 (Cullin 9)
    almost2years
    TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9. (PubMed, Breast Cancer Res)
    Our study reveals that TMEM120B bound to and stabilized MYH9 by preventing its degradation. This interaction activated the β1-integrin/FAK-TAZ-mTOR signaling axis, maintaining stemness and accelerating chemotherapy resistance.
    Journal
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    MYH9 (Myosin Heavy Chain 9) • CUL9 (Cullin 9)
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    docetaxel • doxorubicin hydrochloride
    2years
    A recurrence-predictive model based on eight genes and tumor mutational burden/microsatellite instability status in Stage II/III colorectal cancer. (PubMed, Cancer Med)
    In conclusion, the G8plus score is a powerful biomarker for predicting the risk of recurrence in patients with stage II/III CRC. It can be used to stratify patients who benefit from ACT and immunotherapy.
    Journal • Tumor mutational burden • Microsatellite instability • IO biomarker • Predictive model
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • PCDHA1 (Protocadherin Alpha 1) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) • CUL9 (Cullin 9)
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    TLS gene signature
    2years
    Evaluation of Neddylation and Apoptosis-Related Gene Expression in Patients with Acute Myeloid Leukemia (ASH 2023)
    Intensive treatment was introduced in 43% of pts, while 25% were treated with azacitidine+venetoclax. Our preliminary results did not prove significant differences in the effect of neddylation gene expression levels on the prognosis of AML patients. As studies are emerging on the potential of neddylation-targeted therapies, we are conducting further research to verify the effect of neddylation on AML.
    Clinical
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    FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1) • BCL2L11 (BCL2 Like 11) • CUL4A (Cullin 4A) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CUL1 (Cullin 1) • PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) • CASP7 (Caspase 7) • CUL7 (Cullin 7) • BAK1 (BCL2 Antagonist/Killer 1) • BBC3 (BCL2 Binding Component 3) • CUL2 (Cullin 2) • NEDD8 (NEDD8 Ubiquitin Like Modifier) • CUL9 (Cullin 9)
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    FLT3-ITD mutation • FLT3 mutation • NPM1 mutation • BCL2 expression • BAX expression • BCL2L1 underexpression
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    Venclexta (venetoclax) • azacitidine
    over2years
    Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma. (PubMed, Endokrynol Pol)
    These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.
    Journal
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    CUL2 (Cullin 2) • CUL9 (Cullin 9)
    over2years
    The probiotic-induced disregulation of immune-related genes in colon cells and relation with colorectal cancer. (PubMed, Cell Mol Biol (Noisy-le-grand))
    Also, immune-related pathways were determined that contribute to colorectal cancer formation and progression, as well as genes with opposing roles. This suggests that the length and dosage of probiotic use, in addition to the specific bacterial strain, maybe the most important determinants in the association between probiotics and colorectal cancer.
    Journal
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    IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) • CUL9 (Cullin 9)
    over2years
    Prion protein-dependent regulation of p53-MDM2 crosstalk during endoplasmic reticulum stress and doxorubicin treatments might be essential for cell fate in human breast cancer cell line, MCF-7. (PubMed, Exp Cell Res)
    In conclusion, PrP may be important in determining the fate of cell death through crosstalk between proteins such as p53 and MDM2 under endoplasmic reticulum (ER) stress conditions. Further studies are needed to obtain in-depth information on these potential molecular networks.
    Preclinical • Journal
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    MDM2 (E3 ubiquitin protein ligase) • CUL9 (Cullin 9)
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    TP53 expression
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    doxorubicin hydrochloride