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    BIOMARKER:

    CUL7 overexpression

    i
    Other names: CUL-7, Cullin 7, KIAA0076
    Entrez ID:
    9820
    6ms
    Cullin7 induces docetaxel resistance by regulating the protein level of the antiapoptotic protein Survivin in lung adenocarcinoma cells. (PubMed, J Thorac Dis)
    Cul7 and Survivin were both highly expressed in docetaxel-resistant LUAD cells. Our results suggest that Cul7 may inhibit apoptosis and promote the proliferation of LUAD cells by increasing the Survivin protein level, which in turn contributes to docetaxel chemoresistance in LUAD.
    Journal
    |
    BIRC5 (Baculoviral IAP repeat containing 5) • CUL7 (Cullin 7)
    |
    BIRC5 expression • BIRC5 overexpression • CUL7 overexpression
    |
    docetaxel
    over1year
    Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma. (PubMed, Front Immunol)
    In addition, PPI network analysis showed that CUL7 was closely related to FBXW8, and further pathway enrichment analysis showed that CUL7 was mainly involved in ubiquitin-mediated proteolysis. Therefore, our study provides a comprehensive understanding of the potential role of CUL7 in different tumors, and CUL7 might be a prognostic marker for COAD.
    Journal
    |
    CUL7 (Cullin 7)
    |
    CUL7 overexpression