News - CUL4B expression

2years

Histone ubiquitination-related gene CUL4B promotes lung adenocarcinoma progression and cisplatin resistance. (PubMed, Front Genet)

Notably, we observed higher CUL4B expression among those who responded positively to immunotherapy. These findings underscore the significance of CUL4B in the resistance to cisplatin in lung cancer, highlighting its potential as a therapeutic target.

2 years ago

Journal • IO biomarker • Epigenetic controller

CD8 (cluster of differentiation 8) • CUL4B (Cullin 4B)

CUL4B elevation • CUL4B expression

cisplatin

over2years

Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma. (PubMed, Int J Mol Sci)

We further analyzed ACC Meso-1 xenograft tumor tissues treated with the cullin inhibitor, pevonedistat, which targets protein neddylation, and observed the downregulation of human TGF-β1 and MMP2. In summary, our data suggest that CUL4B overexpression is important for tumor cell growth and survival and may drive PM aggressiveness via the regulation of TGF-β1 expression and, furthermore, reveal a new mechanism of action of pevonedistat.

over 2 years ago

Journal

BIRC5 (Baculoviral IAP repeat containing 5) • YAP1 (Yes associated protein 1) • CUL4A (Cullin 4A) • MMP2 (Matrix metallopeptidase 2) • TGFB1 (Transforming Growth Factor Beta 1) • CTGF (Connective tissue growth factor) • CUL4B (Cullin 4B)

CUL4B expression

pevonedistat (MLN4924)

almost3years

Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. (PubMed, J Biochem Mol Toxicol)

And the absence of circMFN2 inhibited tumor growth in vivo. CircMFN2 repressed OC progression by regulating the miR-198/CUL4B axis.

almost 3 years ago

Journal

CUL4B (Cullin 4B) • MFN2 (Mitofusin 2) • MIR198 (MicroRNA 198) • MIR330 (MicroRNA 330)

CUL4B expression

almost4years

CUL4B is a Potential Novel Prognostic Biomarker and is Correlated with Immune Infiltrates in Malignant Pleural Mesothelioma. (PubMed, Int J Gen Med)

Finally, our results identified CUL4B high expression in MPM cell line NCI-H2052 (epithelioid), MSTO-211H (biphasic), and NCI-H28 (sarcomatoid). CUL4B is a valuable prognostic biomarker and a critical immune cell infiltration regulator in MPM.

almost 4 years ago

Journal

PTEN (Phosphatase and tensin homolog) • IGFBP3 (Insulin-like growth factor binding protein 3) • CUL4B (Cullin 4B)

CUL4B expression

over4years

lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. (PubMed, Cell Death Differ)

Moreover, LV-sh-THAP7-AS1 treatment could suppress GC growth, invasion and metastasis, indicating that THAP7-AS1 may act as a promising molecular target for GC therapies. Taken together, our results show that THAP7-AS1, transcriptionally activated by SP1 and then modified by METTL3-mediated m6A, exerts oncogenic functions, by promoting interaction between NLS and importin α1 and then improving the CUL4B protein entry into the nucleus to repress the transcription of miR-22-3p and miR-320a.

over 4 years ago

Journal

EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • MIR320A (MicroRNA 320a) • CUL4B (Cullin 4B) • METTL3 (Methyltransferase Like 3)

miR-320a expression • CUL4B expression

over4years

CRL4B complex promotes the development of pancreatic cancer by inhibiting secreted frizzled related protein 1 (PubMed, Zhonghua Zhong Liu Za Zhi)

CRL4B complex inhibits the transcription of target gene SFRP1 and promotes the development of pancreatic cancer. Moreover, CRL4B complex is upregulated in pancreatic cancer, which provide a potential of therapeutic target for pancreatic cancer.

over 4 years ago

Journal

FN1 (Fibronectin 1) • VIM (Vimentin) • DDB1 (Damage Specific DNA Binding Protein 1) • SFRP1 (Secreted frizzled related protein 1) • CUL4B (Cullin 4B)

CUL4B expression