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BIOMARKER:

CUL4A expression

i
Other names: CUL4A, Cullin 4A, Cullin-4A, CUL-4A
Entrez ID:
Related biomarkers:
7ms
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma. (PubMed, Cancer Genomics Proteomics)
Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.
Journal
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CUL4A (Cullin 4A) • CDT1 (Chromatin Licensing And DNA Replication Factor 1) • H2AX (H2A.X Variant Histone) • MCM7 (Minichromosome Maintenance Complex Component 7)
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CUL4A expression
over1year
CUL4A silencing attenuates cervical carcinogenesis and improves Cisplatin sensitivity. (PubMed, Mol Cell Biochem)
Taken together, our study underscores CUL4A as a cervical cancer oncogene and illustrates its potential as a prognosis indicator. Our investigation provides a novel avenue in improving current anti-cervical cancer therapy and overcoming the bottle-neck of Cisplatin resistance.
Journal
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CUL4A (Cullin 4A)
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CUL4A overexpression • CUL4A expression
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cisplatin
almost2years
Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A. (PubMed, World J Gastroenterol)
We indicated a potential role of CENPK in promoting tumor proliferation, and it may be a novel diagnostic and prognostic biomarker for CRC.
Journal
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CUL4A (Cullin 4A) • FBXO32 (F-Box Protein 32)
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CUL4A overexpression • CUL4A expression
over2years
The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA. (PubMed, Hemasphere)
As CUL4A needs to be activated by neddylation to facilitate the degradation of several proteins including PCNA, we propose a novel explanation for the synergism between cytarabine and the neddylation inhibitor pevonedistat by inhibition of translesion synthesis. In keeping with this, in AML patients treated with cytarabine, we found high expression of CUL4A and TP73 to be associated with poor prognosis.
Journal
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CUL4A (Cullin 4A) • PCNA (Proliferating cell nuclear antigen) • REV3L (REV3 Like DNA Directed Polymerase Zeta Catalytic Subunit) • TP73 (Tumor Protein P73)
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CUL4A overexpression • CUL4A expression
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cytarabine • pevonedistat (MLN4924)
over2years
Yeast β-glucan increases etoposide sensitivity in lung cancer cell line A549 by suppressing Nrf2 via the non-canonical NF-κB pathway. (PubMed, Mol Pharmacol)
The present study revealed a novel resistance-modifying property of β-glucan, thereby expanding our knowledge on the beneficial roles of β-glucan and providing an alternative strategy to prevent drug resistance by cancer. The present results provide evidence for the involvement of a novel mode of NF-κB and Nrf2 crosstalk in the drug resistance phenotype.
Preclinical • Journal
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KEAP1 (Kelch Like ECH Associated Protein 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • CUL4A (Cullin 4A) • RELB (RELB Proto-Oncogene)
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KEAP1 mutation • CUL4A expression
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etoposide IV
over2years
Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma. (PubMed, Bioengineered)
In addition, its knockdown likewise reversed the facilitating impact of CUL4A expression on tumor growth and declined the expression levels of proliferation-, migration-, and NF-κB signaling-related protein in the tumor. Together, this paper indicated that CUL4A promoted the proliferative, invasive, and migratory aptitude of NPC cells as well as tumor growth by promoting PRMT5 to activate NF-κB signaling.
Journal
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CUL4A (Cullin 4A) • PRMT5 (Protein Arginine Methyltransferase 5)
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CUL4A overexpression • CUL4A expression
3years
Autophagy Plays a Role in the CUL4A-Related Poor Prognosis of Intrahepatic Cholangiocarcinoma. (PubMed, Pathol Oncol Res)
CUL4A promotes autophagy, and exhibits significantly higher autophagic flux which affects the proliferation of iCCA cells; these effects correlated with advance tumor stage and poor prognosis. Thus, targeting autophagy may be potentially therapeutic in iCCA.
Journal
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CUL4A (Cullin 4A)
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CUL4A overexpression • CUL4A expression