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DRUG:

CTX131

i
Other names: CTX131, CTX-131, CTX 131
Associations
Trials
Company:
CRISPR Therap
Drug class:
CD70-targeted CAR-T immunotherapy
Associations
Trials
4ms
Enrollment open
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CTX131
5ms
New P1/2 trial
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CTX131
8ms
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma. (PubMed, Cancer Discov)
Finally, we report on a next-generation CAR T construct, CTX131, in which synergistic potency edits to CTX130 confer improved expansion and efficacy in preclinical studies. Although the role of CAR T cells is well established in hematologic malignancies, the clinical experience in solid tumors has been disappointing. This clinical trial demonstrates the first complete response in a patient with RCC, reinforcing the potential benefit of CAR T cells in the treatment of solid tumors.
Journal • CAR T-Cell Therapy • Metastases
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CD70 (CD70 Molecule)
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CTX130 • CTX131