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    BIOMARKER:

    CSMD1 overexpression

    i
    Other names: CSMD1, CUB And Sushi Multiple Domains 1, Protein Phosphatase 1, Regulatory Subunit 24, CUB And Sushi Domain-Containing Protein 1, CUB And Sushi Multiple Domains Protein 1, KIAA1890, PPP1R24
    Entrez ID:
    64478
    over2years
    CSMD1 suppresses cancer progression by inhibiting proliferation, epithelial-mesenchymal transition, chemotherapy-resistance and inducing immunosuppression in esophageal squamous cell carcinoma. (PubMed, Exp Cell Res)
    Further investigation showed that CSMD1 expression on tumor cells was positively correlated with CD8 T cells infiltration and cytokines secretion. These findings highlight that CSMD1 is a tumor suppressor gene in ESCC patients and a positive regulator of CD8 T cells expansion and activation, and could increase cytokines secretion, indicating that tumor cell-associated CSMD1 might be a target for ESCC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CSMD1 (CUB And Sushi Multiple Domains 1)
    |
    CSMD1 overexpression
    over3years
    Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy. (PubMed, J Exp Clin Cancer Res)
    Our results indicate that CSMD1 cross-talks with the EGFR endosomal trafficking cascade in a way that renders highly invasive breast cancer cells sensitive to chemotherapy. Our study unravels one possible underlying molecular mechanism of CSMD1 tumor suppressor function and may provide novel avenues for design of better treatment.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • CSMD1 (CUB And Sushi Multiple Domains 1)
    |
    CSMD1 overexpression
    |
    gefitinib