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GENE:

CRYAB (Crystallin Alpha B)

News alerts, weekly reports and conference planners

24d

Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)

In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.

24 days ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

27d

First Glance at Myeloid Leukaemia Factor 2 in Cardiomyocytes. (PubMed, J Cardiovasc Dev Dis)

Functionally, MLF2 was significantly upregulated in mouse models of heart failure and in two in vitro models of cardiomyocyte hypertrophy, and its overexpression resulted in attenuation of pro-hypertrophic gene expression. Taken together, these findings provide initial evidence supporting a role for MLF2 in regulating protein homeostasis and in modulating hypertrophic signalling in cardiomyocytes.

27 days ago

Journal

CRYAB (Crystallin Alpha B)

3ms

A mitochondrial lipid metabolism-related gene signature predicts prognosis and immune landscape in colorectal cancer. (PubMed, Front Immunol)

Furthermore, in vitro experiments demonstrated that knockdown of two key genes, ABHD4 and YJEFN3, significantly suppressed CRC cell proliferation, migration, and invasion, supporting their potential oncogenic roles. This mitochondrial lipid metabolism-based risk model represents a promising prognostic biomarker, offering potential guidance for personalized therapeutic strategies in CRC management.

3 months ago

Journal • Tumor mutational burden • Gene Signature • IO biomarker

TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • MAPK1 (Mitogen-activated protein kinase 1) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • ATG7 (Autophagy Related 7) • CRYAB (Crystallin Alpha B) • HDAC3 (Histone Deacetylase 3)

3ms

Gene Signature Associated with Ferroptosis for Predicting Overall Survival among Ovarian Cancer Patients. (PubMed, J Cancer)

Their regulation affects various aspects of OC, including the cell cycle, proliferation, invasiveness, immune response, and drug tolerance. To summarize, ferroptosis significantly impacts the prognosis of OC, and the targeting of relevant pathways holds potential for enhancing treatment outcomes, thereby guiding future research and personalized therapeutic strategies.

3 months ago

Journal • Gene Signature

SLC7A11 (Solute Carrier Family 7 Member 11) • CRYAB (Crystallin Alpha B)

4ms

Stress granule regulator-associated genes predict drug sensitivity, immune infiltration, and prognosis in patients with gastric cancer: Insights from bioinformatic and experimental approaches. (PubMed, Arab J Gastroenterol)

FHL1, TMPO, SERPINE1, and CRYAB are potential prognostic markers in GC. CRYAB may facilitate GC progression by regulating G3BP1-mediated SG assembly.

4 months ago

Journal

SERPINE1 (Serpin Family E Member 1) • CRYAB (Crystallin Alpha B) • G3BP1 (G3BP Stress Granule Assembly Factor 1)

4ms

Enhanced cargo of plasma alpha B crystallin in oligodendrocyte-derived exosomes accompanied by elevated expression of inflammatory factors in the temporal cortex of patients with refractory epilepsy. (PubMed, Biochim Biophys Acta Mol Basis Dis)

The finding that plasma oligodendrocyte-derived exosomal CRYAB is upregulated in patients with epilepsy highlights a potential role of oligodendrocyte-secreted CRYAB in its pathogenesis.

4 months ago

Journal

CRYAB (Crystallin Alpha B)

7ms

Characterizing oligodendrocyte-lineage cells and myelination in the basolateral amygdala: Insights from a novel methodology in postmortem human brain. (PubMed, Psychiatry Res)

Furthermore, no group differences were seen in cell densities or myelin coverage. This study validates a novel sorting method and provides a comprehensive characterization of OL-lineage gene expression, cell densities, and myelin in the human BLA.

7 months ago

Journal

PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • SOX10 (SRY-Box 10) • NEFH (Neurofilament Heavy) • CRYAB (Crystallin Alpha B)

7ms

PANoptosis-driven molecular stratification in esophageal squamous cell carcinoma: A multi-omics prognostic model and FGFR-Targeted therapeutic validation. (PubMed, Comput Biol Med)

This study developed and validated the first prognostic model for ESCC based on PANoptosis, highlighting FGFR inhibitors as potential therapeutic strategies for targeting specific subtypes through the suppression of EMT and modulation of the MYC/E2F pathways.

7 months ago

Journal

ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • FGFR (Fibroblast Growth Factor Receptor) • CCNE1 (Cyclin E1) • CEACAM1 (CEA Cell Adhesion Molecule 1) • CRYAB (Crystallin Alpha B) • PLAU (Plasminogen Activator)

fexagratinib (ABSK091)

7ms

Expression characteristics and biological significance of exosome-related genes in lung cancer. (PubMed, Discov Oncol)

This study unveils the expression characteristics and biological significance of exosome-associated genes in lung cancer. The differential expression of these genes not only offers potential biomarkers for early diagnosis of lung cancer but also lays a foundation for further research into their biological functions in this disease.

7 months ago

Journal

BIRC5 (Baculoviral IAP repeat containing 5) • CAV1 (Caveolin 1) • IL17A (Interleukin 17A) • PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase) • CRYAB (Crystallin Alpha B) • HYAL1 (Hyaluronidase 1) • SLC2A1 (Solute Carrier Family 2 Member 1)

celecoxib oral

8ms

Nuclear factor IA-mediated transcriptional regulation of crystallin αB inhibits hepatocellular carcinoma progression. (PubMed, Mol Clin Oncol)

This pro-tumor effect was reversed in the si-NFIA + si-CRYAB group, where simultaneous downregulation of CRYAB significantly reduced cell proliferation, migration and invasion, suggesting that CRYAB downregulation can counteract the effects induced by low NFIA expression. To conclude, these results suggest that NFIA can inhibit the malignant proliferation of HCC cells by activating CRYAB expression, which further suggest that CRYAB and NFIA are promising avenues for the development of novel HCC treatment strategies.

8 months ago

Journal

CRYAB (Crystallin Alpha B)

10ms

Decreased Expression of Alzheimer's Disease-Related Genes in Cancer May Contribute to the Inverse-Relationship-a Computational Study. (PubMed, ACS Omega)

Three (3) of these genes, AQP1, CRYAB, and HSPB2, were downregulated in all three cancers and may play an important role in reduced risk of cancer development while upregulated in AD. This study serves as a foundational effort to delve deeper into the molecular connections between AD and various cancer types, using the identified genes as a promising starting point for future experimental investigations to fully elucidate the mechanisms involved in the inverse interaction and protection of AD patients against cancer development.

10 months ago

Journal

AQP1 (Aquaporin 1) • CRYAB (Crystallin Alpha B)

11ms

Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease. (PubMed, Acta Neuropathol Commun)

Shared interactions, specifically SYNGR3, between MSA and PD/DLB suggest that neuronal axons are the origin of both diseases. In conclusion, we provide αsyn protein interaction maps for two distinct synucleinopathies.

11 months ago

Journal

CRYAB (Crystallin Alpha B) • GFAP (Glial Fibrillary Acidic Protein) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)