CRY2 (Cryptochrome Circadian Regulator 2)

News alerts, weekly reports and conference planners

10ms

Cry2 Alleviates Cisplatin-Induced Cytotoxicity in Mouse Renal Cortex Tubular Cell Lines. (PubMed, Biol Pharm Bull)

Moreover, Cry2 overexpression upregulated the efflux-related transporters (Atp7a and Mrp2). These results suggest that Cry2 protects against cisplatin toxicity by reducing Pt accumulation and increasing the expression of Atp7a and Mrp2.

10 months ago

Preclinical • Journal

PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • ATP7A (ATPase Copper Transporting Alpha) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1) • PER3 (Period Circadian Regulator 3)

cisplatin

10ms

Integrated machine learning constructed a circadian-rhythm-related model to assess clinical outcomes and therapeutic advantages in hepatocellular carcinoma. (PubMed, Transl Cancer Res)

We proposed a CR-related risk classifier in HCC, to predict patients' overall survival (OS) and therapeutic response. Targeting CR could be a promising treatment modality against HCC.

10 months ago

Clinical data • Journal

CRY2 (Cryptochrome Circadian Regulator 2) • PPARGC1A (PPARG Coactivator 1 Alpha)

over1year

Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation. (PubMed, Genes Cells)

Cry2, which is regulated by the Skp1-Cul1-FBXL3 (SCFFBXL3) ubiquitin ligase complex by binding to FBXL3, can form a complex with E2F1 and c-Myc, which we think is the mechanism to degrade them. Our study revealed a previously unknown mechanism by which exercise prevents cancer development.

over 1 year ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CUL1 (Cullin 1) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1) • E2F1 (E2F transcription factor 1)

MYC expression

over1year

A majority of circadian clock genes are expressed in estrogen receptor and progesterone receptor status-dependent manner in breast cancer. (PubMed, J Biosci)

We note that our findings are not always parallel to the observations reported in previous studies with smaller sample sizes performed in different populations and organisms. Our study suggests that receptor status in breast cancer (thus, subtype of breast cancer) might be more important than previously shown in terms of its influence on the expression of circadian clock genes and on the disruption of the circadian clock, and that ER or PR might be important regulators of breast cancer chronobiology that should be taken into account in personalized chronotherapies.

over 1 year ago

Journal • BRCA Biomarker

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • CLOCK (Clock Circadian Regulator) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1) • PER3 (Period Circadian Regulator 3) • NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1)

over1year

Comprehensive analysis of distinct circadian clock subtypes of adult diffuse glioma and their associations with clinicopathological, genetic, and epigenetic profiles. (PubMed, J Neuropathol Exp Neurol)

Stratified Kaplan-Meier and multivariable Cox analyses illustrated that the CC subtype is an independent prognostic factor to clinicopathological characteristics (P < .001), genetic aberrations (P = .006), and biological processes (P < .001). Thus, this study shows statistical evidence of CC subtypes and their biological, and clinicopathological significance in adult gliomas.

over 1 year ago

Journal

PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • CRY2 (Cryptochrome Circadian Regulator 2)

2years

Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice. (PubMed, Environ Health Prev Med)

These results suggest that CuCl-induced diurnal toxicity is associated with Cry2 and Per1 expression through the regulation of copper transporter genes in mice.

2 years ago

Preclinical • Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CLOCK (Clock Circadian Regulator) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1)

CRY2 mutation

over3years

Clock genes in breast cancer (SABCS 2022)

Dysregulation of clock genes is strongly associated with breast cancer subtype and survival. Higher CS is associated with TNBC and PDL1 expression and supports the use of checkpoint inhibitors. Prognosis is better with low expression of TIMELESS and CLOCK and high expression of CRY2 and PER2/3, suggesting a role in tumor development and maintenance.

over 3 years ago

PD(L)-1 Biomarker • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • STK11 (Serine/threonine kinase 11) • CD8 (cluster of differentiation 8) • KMT2C (Lysine Methyltransferase 2C) • CDH1 (Cadherin 1) • CD4 (CD4 Molecule) • PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • HMGA2 (High mobility group AT-hook 2) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • CLOCK (Clock Circadian Regulator) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1) • TIMELESS (Timeless Circadian Regulator)

PD-L1 expression • TP53 mutation • HER-2 negative • PIK3CA mutation • HER-2 expression • STK11 mutation • CDH1 mutation • PD-L1 expression + HER-2 overexpression • CRY2 mutation