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    BIOMARKER:

    CRY2 mutation

    i
    Other names: CRY2, Cryptochrome Circadian Regulator 2, Cryptochrome 2 (Photolyase-Like), Cryptochrome Circadian Clock 2, Cryptochrome-2, Growth-Inhibiting Protein 37, KIAA0658, HCRY2, PHLL2
    Entrez ID:
    1408
    2years
    Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice. (PubMed, Environ Health Prev Med)
    These results suggest that CuCl-induced diurnal toxicity is associated with Cry2 and Per1 expression through the regulation of copper transporter genes in mice.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CLOCK (Clock Circadian Regulator) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1)
    |
    CRY2 mutation
    over3years
    Clock genes in breast cancer (SABCS 2022)
    Dysregulation of clock genes is strongly associated with breast cancer subtype and survival. Higher CS is associated with TNBC and PDL1 expression and supports the use of checkpoint inhibitors. Prognosis is better with low expression of TIMELESS and CLOCK and high expression of CRY2 and PER2/3, suggesting a role in tumor development and maintenance.
    PD(L)-1 Biomarker • IO biomarker
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • STK11 (Serine/threonine kinase 11) • CD8 (cluster of differentiation 8) • KMT2C (Lysine Methyltransferase 2C) • CDH1 (Cadherin 1) • CD4 (CD4 Molecule) • PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • HMGA2 (High mobility group AT-hook 2) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • CLOCK (Clock Circadian Regulator) • CRY2 (Cryptochrome Circadian Regulator 2) • PER1 (Period Circadian Clock 1) • TIMELESS (Timeless Circadian Regulator)
    |
    PD-L1 expression • TP53 mutation • HER-2 negative • PIK3CA mutation • HER-2 expression • STK11 mutation • CDH1 mutation • PD-L1 expression + HER-2 overexpression • CRY2 mutation