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    BIOMARKER:

    CRTAM overexpression

    i
    Other names: CRTAM, Cytotoxic And Regulatory T Cell Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, Cytotoxic And Regulatory T-Cell Molecule, CD355, Class I MHC Restricted T Cell Associated Molecule, CD355 Antigen
    Entrez ID:
    56253
    3ms
    CRTAM promotes antitumor immune response in triple negative breast cancer by enhancing CD8+ T cell infiltration. (PubMed, Int Immunopharmacol)
    We also found that CRTAM enhanced tumor-associated immune cell infiltration, especially CD8+ T cells, which may be related to the increased expression of MHC class I molecules caused by CRTAM overexpression. These results suggest that CRTAM may serve as a potential biomarker for predicting the efficacy of immunotherapy in TNBC.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • CRTAM (Cytotoxic And Regulatory T Cell Molecule)
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    CRTAM overexpression