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    BIOMARKER:

    CRTAC1 overexpression

    i
    Other names: CRTAC1, Cartilage Acidic Protein 1, CEP-68, ASPIC1, FLJ10320, ASPIC, CEP68, Chondrocyte Expressed Protein 68 KDa CEP-68, Acidic Secreted Protein In Cartilage, 68 KDa Chondrocyte-Expressed Protein, LOTUS
    Entrez ID:
    55118
    almost2years
    CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma. (PubMed, Sci Rep)
    Upregulation of CRTAC1 significantly inhibited LUAD cell proliferation, invasion, and migration in cellular experiments. CRTAC1 has the potential to serve as a diagnostic and prognostic biomarker in LUAD.
    Journal
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    CRTAC1 (Cartilage Acidic Protein 1)
    |
    CRTAC1 overexpression
    over2years
    CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression. (PubMed, Cell Death Dis)
    Taken together, the present results indicate that CRTAC1 overexpression increases the chemosensitivity of NSCLC to cisplatin treatment by inducing Ca-dependent Akt1 degradation and apoptosis, suggesting the potential of CRTAC1 as a biomarker for predicting cisplatin chemosensitivity. Our results further reveal that modulating the expression of CRTAC1 could be a new strategy for increasing the efficacy of cisplatin in chemotherapy of NSCLC patients.
    Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CRTAC1 (Cartilage Acidic Protein 1)
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    CRTAC1 overexpression
    |
    cisplatin