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    BIOMARKER:

    CRKL mutation

    i
    Other names: CRKL, CRK Like Proto-Oncogene, Adaptor Protein, V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like, Crk-Like Protein
    Entrez ID:
    1399
    Related biomarkers:
    Expression
    CNA
    Others
    over1year
    Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism. (PubMed, Genomics)
    Furthermore, inhibiting CRKL expression in melanoma cell lines suppressed their proliferation and metastasis, as well as activated pyroptosis-related pathway. Our study provides important insights into the underlying mechanisms of melanoma pathogenesis and identifies new opportunities for targeted therapy in this disease.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
    |
    TMB (Tumor Mutational Burden) • CRKL (CRK Like Proto-Oncogene, Adaptor Protein)
    |
    CRKL mutation