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    BIOMARKER:

    CRIPTO expression

    i
    Other names: CRIPTO, Cripto, EGF-CFC Family Member, Teratocarcinoma-Derived Growth Factor 1, CR-1, CR, Epidermal Growth Factor-Like Cripto Protein CR1, Cripto-1 Growth Factor, Cripto-1, TDGF1, CRGF, CRIPTO
    Entrez ID:
    6997
    26d
    CRIPTO's multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data. (PubMed, Oncogene)
    Transcriptomic analyses revealed a unique CRIPTO/MYC co-activation signature associated with PSA progression in a human PCa cohort. Taken together, our data highlights a role for CRIPTO in tumor invasiveness and progression, which carries implications for biomarkers and targeted therapies.
    Preclinical • Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CRIPTO (Cripto) • NKX3-1 (NK3 homeobox 1)
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    CRIPTO expression
    1m
    Human Cripto-1 and Cripto-3 Protein Expression in Normal and Malignant Settings That Conflicts with Established Conventions. (PubMed, Cancers (Basel))
    Our discriminatory MoAbs provide new reagents to help clarify current CR1/CR3 protein expression vagaries in the Cripto field of study, challenging established CR1 conventions. In addition, our data validate CR3 involvement in human carcinogenesis and cell signaling pathways, with potential clinical relevance in determining cancer patient prognosis and disease severity.
    Journal
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    HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • CRIPTO (Cripto)
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    CRIPTO expression