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    BIOMARKER:

    CRIP1 overexpression

    i
    Other names: CRIP1, Cysteine Rich Protein 1, CRIP, Cysteine-Rich Protein 1 (Intestinal), Cysteine-Rich Intestinal Protein, Cysteine-Rich Heart Protein, Cysteine-Rich Protein 1, CRP-1, CRHP, CRP1, HCRHP
    Entrez ID:
    1396
    2years
    CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy. (PubMed, EBioMedicine)
    Our findings clarified the pivotal roles of the CRIP1/USP7/PA200 complex in ubiquitin-dependent proteasome degradation and autophagy maturation involved in the pathogenesis of MM.
    Journal
    |
    CRIP1 (Cysteine Rich Protein 1) • USP7 (Ubiquitin Specific Peptidase 7)
    |
    CRIP1 overexpression
    over2years
    CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis. (PubMed, Adv Sci (Weinh))
    The study highlights CRIP1 regulates the tumor microenvironment to promote lymphangiogenesis and LM in GC. Considering the current limited understanding of LM development in GC, these pathways provide potential targets for future therapeutics.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • CCL5 (Chemokine (C-C motif) ligand 5) • VEGFC (Vascular Endothelial Growth Factor C) • CREB1 (CAMP Responsive Element Binding Protein 1) • CRIP1 (Cysteine Rich Protein 1)
    |
    CRIP1 overexpression
    over2years
    CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma. (PubMed, Gut)
    The CRIP1/NF-κB/CXCL axis is critical for triggering immune evasion and TIME formation in PDAC. Blockade of this signalling pathway prevents MDSC trafficking and thereby sensitises PDAC to immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CRIP1 (Cysteine Rich Protein 1) • CXCR1 (Chemokine (C-X-C motif) receptor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
    |
    CRIP1 overexpression
    |
    SX-682