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    BIOMARKER:

    CREBBP deletion

    i
    Other names: CREBBP, CBP, KAT3A, RSTS, RTS, CREB binding protein
    Entrez ID:
    1387
    Related biomarkers:
    Mutation
    Others
    over1year
    The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice. (PubMed, Oncogenesis)
    In summary, we demonstrate the oncogenic potential of a combined loss of function of CREBBP and overexpression of MYCN in this cell population. hGFAP-cre::Crebbp::lsl-MYCN mice thus provide a valuable tool to study tumor-driving mechanisms in a key neural stem/ progenitor cell niche.
    Preclinical • Journal
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    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • CREBBP (CREB binding protein)
    |
    CREBBP deletion • MYCN expression