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    GENE:

    CR1 (Complement C3b/C4b Receptor 1)

    i
    Other names: CR1, Complement C3b/C4b Receptor 1 (Knops Blood Group), CD35, KN, Complement Component (3b/4b) Receptor 1 (Knops Blood Group), Complement Receptor Type 1, C3b/C4b Receptor, CD35 Antigen, C3BR, Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System, Complement Component 3b/4b Receptor 1 (Knops Blood Group), Knops Blood Group Antigen, Complement Receptor 1, C3-Binding Protein, C4BR
    Associations

    News

    Trials
    12d
    Diagnostic challenges in primary pulmonary follicular dendritic cell sarcoma: 2 case reports. (PubMed, BMC Pulm Med)
    FDCS has a unique histological morphology and immunophenotype for FDCS. It is rare for FDCS to occur in the lungs. However, owing to the lack of experience among doctors and the limitations of small biopsy specimens, FDCS can easily be misdiagnosed as lung cancer. When tumour cells exhibit the above histological features, additional immunostaining for FDC markers should be performed. The Clinical Trial Number is ChiCTR2400090730 and Reg Date is October 12, 2024.
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    CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
    1m
    A pleura-based follicular dendritic cell sarcoma with epithelioid morphology and aberrant expression of cytokeratins. (PubMed, J Hematop)
    FDCS is a rare neoplasm with variable morphologic and staining patterns. To the best of our knowledge, this is the first reported instance of pleura-based FDCS with epithelioid morphology and aberrant expression of cytokeratins. Diagnosis of such cases can be challenging, which has to be separated from the morphologic mimicries, particularly carcinoma and mesothelioma.
    Journal
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    RB1 (RB Transcriptional Corepressor 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CLU (Clusterin) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
    2ms
    Unicentric Castleman disease with paraneoplastic pemphigus and follicular dendritic cell sarcoma: A case report. (PubMed, Oncol Lett)
    Initial therapy comprised high-dose methylprednisolone, intravenous immunoglobulin and thalidomide, followed by surgical resection and adjuvant thalidomide-cyclophosphamide-prednisone. Postoperatively, inflammatory indices normalized and mucocutaneous lesions partially improved; nevertheless, the patient died of respiratory failure 6 months after surgery. In summary, the present case report aimed to provide valuable references and experiences for clinicians in the diagnosis and treatment of CD featuring PNP and FDCS.
    Journal
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    CXCL13 (Chemokine (C-X-C motif) ligand 13) • CD68 (CD68 Molecule) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
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    cyclophosphamide • prednisone • thalidomide • methylprednisolone sodium succinate
    6ms
    Clinicopathological features of lymphoepithelioma-like carcinoma with abnormal expression of follicular dendritic cell markers: report of four cases (PubMed, Zhonghua Bing Li Xue Za Zhi)
    Occasionally, it can overlap with follicular dendritic cell sarcoma by morphology and immunophenotype, which can lead to misdiagnosis. Only by combining clinical information, morphological characteristics and immunophenotype can an appropriate diagnosis be made.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CDH1 (Cadherin 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • SSTR2 (Somatostatin Receptor 2) • VIM (Vimentin) • TP63 (Tumor protein 63) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
    6ms
    Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review. (PubMed, Front Oncol)
    Most cases follow an indolent clinical course and have a favorable prognosis after complete surgical resection, though rare aggressive cases have been reported. Understanding its clinicopathological and molecular features is essential for accurate diagnosis and management.
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    CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
    6ms
    Behavioral investigation of reactive and neoplastic lymphocytes in human lymph nodes in 4D. (PubMed, PLoS One)
    In neoplastic tissue, slower cellular dynamics and fewer interactions were observed compared to reactive tissue. This indicates differences in cellular behavior between reactive and neoplastic tissues, with a more dynamic cellular environment observed in reactive tissue.
    Journal
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    CD20 (Membrane Spanning 4-Domains A1) • PD-1 (Programmed cell death 1) • CR1 (Complement C3b/C4b Receptor 1)
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    CD20 positive
    6ms
    Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome. (PubMed, Ann Rheum Dis)
    Genetic or epigenetic-mediated CR1 deficiency is a potential hallmark of CAPS and predicts response to C5 inhibition.
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    CR1 (Complement C3b/C4b Receptor 1)
    8ms
    Follicular dendritic cell sarcoma of the stomach in a young male: A rare case report and literature review. (PubMed, Medicine (Baltimore))
    Gastric FDCS is easily misdiagnosed as gastrointestinal stromal tumor (GIST) or Castleman disease due to overlapping imaging features. Multimodal imaging (CT, MRI, positron emission tomography/CT) combined with histopathology is critical for accurate diagnosis. Radical surgery remains the cornerstone of treatment, emphasizing the need for wide resection to minimize recurrence. This case provides the first comprehensive imaging characterization of gastric FDCS, enhancing awareness and diagnostic precision for this rare entity.
    Review • Journal
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    CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
    9ms
    A multivariable cis-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias. (PubMed, Brief Bioinform)
    The subsequent analysis revealed a complex protein regulation network that influenced lipid traits. Furthermore, we used cis-MRBEE to discover that the expressions of CR1 in the basal ganglia, hippocampus, and oligodendrocytes were potentially causal for Alzheimer's disease and its biomarkers, A$beta $42 and pTau, in cerebrospinal fluid.
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    APOA1 (Apolipoprotein A-I) • CR1 (Complement C3b/C4b Receptor 1) • ANGPTL3 (Angiopoietin Like 3)
    9ms
    KRAS may facilitate transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features. (PubMed, Am J Clin Pathol)
    We establish by both IGH NGS analysis and mutational profiling that the CLL and HS are clonally-related and posit that acquisition of KRAS p.G13D drove transdifferentiation. This has therapeutic implications for targeting the RAS-BRAF-MAPK-ERK pathway.
    Journal • IO biomarker
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • SF3B1 (Splicing Factor 3b Subunit 1) • CCND1 (Cyclin D1) • BCL6 (B-cell CLL/lymphoma 6) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD163 (CD163 Molecule) • CD33 (CD33 Molecule) • CD4 (CD4 Molecule) • CD68 (CD68 Molecule) • CD79A (CD79a Molecule) • IRF4 (Interferon regulatory factor 4) • MME (Membrane Metalloendopeptidase) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II) • TCF4 (Transcription Factor 4)
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    BRAF V600E • KRAS G13D • RAS mutation • KRAS G13 • CD33 positive
    9ms
    Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS). (PubMed, medRxiv)
    Five patients were treated with C5 inhibition which mitigated thrombosis. Genetic or epigenetic-mediated CR1 deficiency is a potential hallmark of CAPS and predicts response to C5 inhibition.
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    CR1 (Complement C3b/C4b Receptor 1)
    10ms
    Long-Term Survival Following Cladribine Containing Pretransplant Regimen for Autologous Hematopoietic Stem Cell Transplantation in Disseminated Interdigitating Dendritic Cell Sarcoma: A Case Report and Literature Review. (PubMed, J Blood Med)
    Therefore, the long survival of this patient might suggest that ABVD regimen with a sequential cladribine-containing preparative regimen prior to auto-HSCT may improve the prognosis of disseminated IDCS. However, this represents only a single-case experience, and further studies with larger sample sizes are required for validation.
    Journal
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    CD163 (CD163 Molecule) • VIM (Vimentin) • CR1 (Complement C3b/C4b Receptor 1) • FCER2 (Fc Fragment Of IgE Receptor II)
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    cladribine