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    GENE:

    CPNE1 (Copine 1)

    i
    Other names: CPNE1, Copine 1, CPN1, Copine I, Chromobindin 17, Copine-1, COPN1
    Associations

    News

    Trials
    7ms
    Multi-omics dissection of CPNE1 reveals its prognostic value and immune-regulatory function in liver cancer. (PubMed, Discov Oncol)
    CPNE1 is linked to poor prognosis in hepatocellular carcinoma (HCC) and proposes the SNHG6/hsa-miR-101-3p/CPNE1 regulatory axis. The study investigates the role of CPNE1 in modulating the immune microenvironment of liver cancer and suggests that it may serve as a biomarker for poor prognosis in HCC patients.
    Journal
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    CPNE1 (Copine 1) • PPIA (Peptidylprolyl Isomerase A)
    10ms
    Single-cell RNA Sequencing Analysis Reveals the Regulatory Functions of Copines Family Genes in Testicular Cancer Progression. (PubMed, Endocr Metab Immune Disord Drug Targets)
    This study revealed the potential molecular mechanism through which Copines family genes drove the progression of testicular cancer through regulating PI3K-Akt signaling pathway and cell cycle, providing a new target for the development of precision treatment targeting Copines family genes and prognostic assessment of the cancer.
    Journal
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    CCL21 (C-C Motif Chemokine Ligand 21) • CPNE1 (Copine 1)
    10ms
    Identifying causal brain structures, genes and proteins for osteoarthritis: A large-scale genetic correlation study based on brain imaging-derived phenotypes, transcriptomes, and proteomes. (PubMed, J Gerontol A Biol Sci Med Sci)
    This study enhances our understanding of the brain-joint axis in OA genetics, potentially informing new treatment strategies and therapeutic targets.
    Journal
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    CPNE1 (Copine 1)
    1year
    Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis. (PubMed, J Ovarian Res)
    This study provides proof of a causal relationship between genetically predicted 44 proteins associated with OC risk, which could serve as promising drug targets for OC.
    Journal
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    HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • FCGR2B (Fc Fragment Of IgG Receptor IIb) • IL1R1 (Interleukin 1 receptor, type I) • IL6ST (Interleukin 6 Signal Transducer) • LRRC1 (Leucine Rich Repeat Containing 1) • PDIA3 (Protein Disulfide Isomerase Family A Member 3) • SPINK1 (Serine peptidase inhibitor, kazal type 1) • TGFBI (Transforming Growth Factor Beta Induced) • CNTN2 (Contactin 2) • CPNE1 (Copine 1) • PLAU (Plasminogen Activator) • SEMA4D (Semaphorin 4D) • SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9)
    over1year
    Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis. (PubMed, Front Endocrinol (Lausanne))
    The present study identified several novel potential drug targets and biomarkers for breast cancer, providing new insights into its diagnosis and treatment. The integration of PPI and druggability evaluations enhances the prioritization of these therapeutic targets, paving the way for future drug development efforts.
    Journal
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    TNFRSF9 (TNF Receptor Superfamily Member 9) • CASP8 (Caspase 8) • BTN2A1 (Butyrophilin Subfamily 2 Member A1) • CPNE1 (Copine 1) • DDX58 (DExD/H-Box Helicase 58)
    over1year
    Integrated ubiquitomics characterization of hepatocellular carcinomas. (PubMed, Hepatology)
    This study expands our knowledge of ubiquitomic signatures, biomarkers, and potential therapeutic targets in HCC.
    Journal
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    COL4A1 (Collagen Type IV Alpha 1 Chain) • CPNE1 (Copine 1) • LAMC1 (Laminin Subunit Gamma 1) • USP14 (Ubiquitin Specific Peptidase 14)
    over1year
    Comprehensive analysis of CPNE1 predicts prognosis and drug resistance in gastric adenocarcinoma. (PubMed, Am J Transl Res)
    CPNE1 could be a predictive biomarker and a potential target for biological therapy in STAD.
    Journal • PARP Biomarker
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    CPNE1 (Copine 1)
    |
    Lynparza (olaparib) • Koselugo (selumetinib) • Iclusig (ponatinib) • pazopanib • Rubraca (rucaparib) • temsirolimus • axitinib • refametinib (BAY86-9766) • AZD8055 • seliciclib (CYC202)
    over1year
    Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma. (PubMed, Acta Pharm Sin B)
    Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination (2/5), which confirmed the critical role of miR-330-3p in OSCC development. These findings provide a new perspective for the development of OSCC treatments.
    Journal
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    CPNE1 (Copine 1) • MIR330 (MicroRNA 330)
    almost2years
    Copines, a Family of Calcium Sensor Proteins and Their Role in Brain Function. (PubMed, Biomolecules)
    Neuronal Copines are implicated in a wide array of processes from cell differentiation to synaptic transmission and plasticity and are also linked to several pathological conditions from cancers to brain diseases. This review provides the most up-to-date insights into the structure and function of Copines, with an emphasis on their role in brain function.
    Review • Journal
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    CPNE1 (Copine 1)
    almost2years
    Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes. (PubMed, Curr Genomics)
    An in-depth multi-dimensional downstream analysis of all these genes in terms of gene expression profiling and analysis and differential gene expression with regard to various cancer types revealed CTSB and CPNE1 as highly expressed and overregulated genes in colorectal cancer. Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.
    Journal
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    MUC4 (Mucin 4, Cell Surface Associated) • PDE4DIP (Phosphodiesterase 4D Interacting Protein) • CPNE1 (Copine 1) • OPRM1 (Opioid Receptor Mu 1) • RAD17 (RAD17 Checkpoint Clamp Loader Component) • SEMA4D (Semaphorin 4D)
    2years
    CPNE1, A Potential Therapeutic Target in Nasopharyngeal Carcinoma, Affects Cell Growth and Radiation Resistance. (PubMed, Radiat Res)
    We observed elevated p-Akt in si-CPNE1 transfected C666-1 and SUNE-1 cells. In conclusion, these results demonstrated that CPNE1 expression is elevated in nasopharyngeal carcinoma cells, and its silencing could attenuate nasopharyngeal carcinoma advancement and improve radiosensitivity to radiation therapy by controlling Akt activation.
    Journal
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    CPNE1 (Copine 1)
    2years
    Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause. (PubMed, Commun Biol)
    Follow-up pathway and gene enrichment analyses demonstrated links between AAM-related proteins and obesity and diabetes, and between AAM and ANM-related proteins and various types of cancer. In conclusion, we identified proteomic signatures of reproductive ageing in women, highlighting biological processes at both ends of the reproductive lifespan.
    Journal
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    FOXO3 (Forkhead box O3) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • CPNE1 (Copine 1) • PLXNA1 (Plexin A1) • SEMA3G (Semaphorin 3G)