CPA6 (Carboxypeptidase A6)

Finally, NOTCH1 could reduce the radiosensitivity of cervical cancer cells to radiotherapy both in vitro and in vivo; whereas has-miR-449a, as an upstream regulatory miRNA of NOTCH1, could inhibit cervical cancer cell proliferation and enhance radiosensitivity by inhibiting NOTCH1 expression. This study clarifies NOTCH1's role in promoting cervical cancer progression and reducing radiosensitivity, with has-miR-449a as a negative regulator, providing targets for optimizing cervical cancer radiotherapy.

The large differences between single nucleotide mutations and insertion-deletion mutations in somatic cells and germ line cells indicate the large changes in the genome, especially in the non-coding region genome, during the transformation of normal tissue adjacent to cancer into cancerous tissue. In addition, the susceptibility gene SH3BP1 found in this study has the role of promoting colorectal cancer, which has good research value and is expected to be a new target for colorectal cancer treatment.

CPA6 has a significant tumor suppressive effect on CRC by inhibiting the activation of Akt/mTOR signaling, and miR-96-3p negatively regulates the expression of CPA6.