P3, N=140, Recruiting, Amsterdam UMC, location VUmc | Not yet recruiting --> Recruiting

P1, N=200, Recruiting, Shandong Suncadia Medicine Co., Ltd. | Not yet recruiting --> Recruiting

The combination also significantly downregulated IL-6, IL-17, and TNF-α levels, and showed potent COX-2 inhibition (0.10 ± 0.01 µg/mL), surpassing celecoxib (0.9 ± 0.05 µg/mL)...Notably, the combination reduced cell viability to 3.77 ± 0.4 % % at 400 µg/mL, consistent with apoptotic changes. Collectively, these findings highlight the synergistic potential of APs and eugenol as a multi-target therapeutic approach against MDR infections, inflammation, oxidative stress, and liver cancer.

Palliative therapy with toceranib phosphate and meloxicam achieved prolonged survival and excellent quality of life, with no adverse effects despite dose escalation...The observed benefit likely reflects toceranib's multi-target activity (VEGFR2, PDGFR), impacting angiogenesis and tumour progression. This case represents the first report of toceranib phosphate use in feline pulmonary carcinoma and underscores its potential as a palliative option.

P3, N=20, Completed, Suez Canal University

P=N/A, N=80, Completed, Istanbul Medeniyet University

P1, N=42, Completed, Laboratorios Silanes S.A. de C.V.

P2/3, N=100, Suspended, Wake Forest University Health Sciences | Recruiting --> Suspended

P3, N=116, Completed, Heron Therapeutics | Phase classification: P3b --> P3

P4, N=150, Not yet recruiting, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Intermediate-region APC mutations (e.g., codons 607 and 1062) predict an indolent course in mesenteric DTs. Comprehensive APC genotyping at diagnosis enables risk-adapted management, permitting safe use of conservative strategies (active surveillance/low-intensity therapy) and helps avoid unnecessary aggressive interventions. This underscores the critical role of molecular profiling in personalizing DT care.

P4, N=86, Enrolling by invitation, Washington University School of Medicine | Not yet recruiting --> Enrolling by invitation