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    DRUG CLASS:

    COX inhibitor

    Related drugs:
    1d
    Adjuvant Aspirin and Cyclooxygenase-2 Inhibitors in Resected, PIK3CA-Mutated Colorectal Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Crit Rev Oncol Hematol)
    Adjuvant NSAID therapy is associated with improved DFS in patients with PIK3CA-mutated CRC. OS benefit remains uncertain, and findings from sensitivity analyses are exploratory. These findings support consideration of NSAIDs as a biomarker-informed adjuvant strategy in selected patients while underscoring the need for confirmatory evidence from ongoing randomized trials.
    Retrospective data • Review • Journal
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
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    PIK3CA mutation
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    aspirin
    2d
    Stroke Rate in Patients With Blunt Cerebrovascular Injury (BCVI) Treated With Oral Acetylsalicylic Acid (ASA) 81 mg Versus ASA 325 mg (BASA). (clinicaltrials.gov)
    P4, N=98, Recruiting, Loma Linda University | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    aspirin
    3d
    An Exploratory Randomized Controlled Clinical Trial Evaluating the Efficacy and Safety of Transcatheter Mitral Valve Edge-to-Edge Repair Combined with Left Atrial Appendage Closure (ChiCTR2600117521)
    P=N/A, N=100, Not yet recruiting, Beijing Anzhen Hospital, Capital Medical University; Beijing Anzhen Hospital, Capital Medical University
    New trial
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    aspirin
    3d
    Comparison of aspirin and rivaroxaban for the prevention of pulmonary embolism and deep vein thrombosis in high thrombotic risk patients with systemic lupus erythematosus (PREVENT-SLE) (ChiCTR2600117175)
    P=N/A, N=456, Not yet recruiting, The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University
    New trial
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    aspirin
    3d
    Comparative Study of Treatment Strategies for Migraine in Patients with Patent Foramen Ovale (PFO): A Multicenter Randomized Controlled Trial of Transcatheter Closure versus Medical Therapy (ChiCTR2600115896)
    P=N/A, N=150, Recruiting, The Seventh Affiliated Hospital Sun Yat-sen University; The?Seventh?Affiliated?Hospital?Sun?Yat-sen?University
    New trial
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    aspirin
    3d
    The effect of vitamin K antagonists on the risk of embolism and major bleeding in patients after mitral valve repair (ChiCTR2500112354)
    P=N/A, N=100, Recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial
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    aspirin
    3d
    The Effect of flurbiprofen axetil on postoperative immune function in patients with bone tuberculosis (ChiCTR2500112190)
    P=N/A, N=120, Completed, Shanghai Public Health Clinical Center; Shanghai Public Health Clinical Center
    New trial
    3d
    Real-World Efficacy and Safety of Dual Antiplatelet Therapy versus Aspirin Monotherapy in Perioperative Carotid Endarterectomy (ChiCTR2500111376)
    P=N/A, N=1800, Not yet recruiting, Zhongshan Hospital Affiliated to Fudan University; Zhongshan Hospital Affiliated to Fudan University
    New trial
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    aspirin
    3d
    To evaluate the efficacy and safety of HR1405-01 injection in the treatment of pain after abdominal surgery in a multi-center, randomized, double-blind, positive drug and placebo parallel controlled phase Ⅲ clinical trial (ChiCTR2500112614)
    P3, N=440, Not yet recruiting, The Third Xiangya Hospital of Central South University; The Third Xiangya Hospital of Central South University
    New P3 trial
    8d
    Maternal Aspirin Treatment Improves Ischemic Stroke Outcome in Adult Male Offspring From Experimental Preeclamptic Dams. (PubMed, Stroke)
    Prenatal exposure to ePE worsened stroke severity and inflammation in male but not female offspring, which was largely mitigated by maternal LDA treatment, potentially due to an improved intrauterine environment. These findings highlight a sex-specific impact of prenatal preeclampsia exposure on long-term cerebrovascular health and suggest that maternal LDA may confer long-lasting protection to the offspring in addition to the mother.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha)
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    aspirin
    10d
    preGO: LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention (clinicaltrials.gov)
    P4, N=100, Recruiting, Alexandra Hospital, Athens, Greece
    New P4 trial
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    aspirin
    10d
    Timed Aspirin Chronobiome Study (clinicaltrials.gov)
    P1, N=60, Not yet recruiting, University of Pennsylvania | Trial completion date: May 2028 --> Nov 2028 | Trial primary completion date: May 2027 --> Jan 2028
    Trial completion date • Trial primary completion date
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    aspirin • celecoxib oral