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    DRUG CLASS:

    COX inhibitor

    Related drugs:
    27d
    Extensive bilateral pulmonary embolism revealing iron deficiency-masked JAK2-positive polycythemia vera: A case report. (PubMed, Radiol Case Rep)
    The patient received therapeutic anticoagulation, low-dose aspirin, and hydroxyurea. This case highlights the role of multimodal imaging in diagnosis and risk stratification, and the need to consider masked polycythemia vera in unprovoked pulmonary embolism with unexplained microcytosis and elevated red blood cell count.
    Journal
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    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • JAK2 (Janus kinase 2)
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    hydroxyurea • aspirin
    27d
    A Study of Combogesic 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery (clinicaltrials.gov)
    P3, N=180, Not yet recruiting, AFT Pharmaceuticals, Ltd. | Trial completion date: Oct 2026 --> Oct 2027 | Initiation date: Feb 2026 --> Oct 2026 | Trial primary completion date: Oct 2026 --> Oct 2027
    Trial completion date • Trial initiation date • Trial primary completion date
    27d
    A Study of Combogesic IV (Intravenous) in Pediatric Patients With Acute Pain (clinicaltrials.gov)
    P3, N=60, Not yet recruiting, AFT Pharmaceuticals, Ltd. | Trial completion date: Oct 2026 --> Apr 2027 | Initiation date: Feb 2026 --> Sep 2026 | Trial primary completion date: Oct 2026 --> Mar 2027
    Trial completion date • Trial initiation date • Trial primary completion date
    28d
    AWATAR: Aspirin Monotherapy Versus Sequential Warfarin-Aspirin Therapy After TAVR in Patients With Pure Aortic Regurgitation (clinicaltrials.gov)
    P=N/A, N=1172, Not yet recruiting, Shanghai Zhongshan Hospital
    New trial
    |
    aspirin
    28d
    Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis (clinicaltrials.gov)
    P2, N=307, Completed, ZetrOZ, Inc. | Trial completion date: Feb 2026 --> Jun 2026 | Trial primary completion date: Feb 2026 --> Jun 2026 | Recruiting --> Completed
    Trial completion • Trial completion date • Trial primary completion date
    29d
    Platelet proteome links metabolism to reactivity in Essential Thrombocythemia. (PubMed, Mol Cell Proteomics)
    Acetylsalicylic acid (ASA) decreased the abundance of metabolic proteins in CALR Type1 platelets, whereas JAK2 V617F platelets showed only minor, heterogeneous increases restricted to a subset of proteins and samples. In functional assays, JAK2 V617F platelets showed aggregation responses similar to or lower than those of healthy controls, whereas untreated CALR Type2 platelets showed higher CD62P expression, indicating a more activated phenotype than the other ET groups. These findings indicate that ET platelets display mutation-associated proteomic and functional differences and suggest that an altered metabolic state may contribute to platelet reactivity.
    Journal
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    JAK2 (Janus kinase 2) • CALR (Calreticulin) • SELP (Selectin P)
    |
    aspirin
    29d
    OASP: Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, Al-Azhar University
    New trial
    |
    aspirin
    1m
    Effect of Preoperative Tramadol and Naproxen Sodium on Post Operative Pain (clinicaltrials.gov)
    P2/3, N=139, Completed, Dow University of Health Sciences | N=47 --> 139
    Enrollment change
    1m
    Optim-PRE: Optimizing the Use of Aspirin for the Prevention of Preeclampsia (clinicaltrials.gov)
    P3, N=15160, Not yet recruiting, Hospital Universitari Vall d'Hebron Research Institute
    New P3 trial
    |
    aspirin
    1m
    INTENSE-TBM: Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis (clinicaltrials.gov)
    P3, N=768, Recruiting, ANRS, Emerging Infectious Diseases | Trial completion date: Apr 2026 --> Sep 2026 | Trial primary completion date: Sep 2025 --> Sep 2026
    Trial completion date • Trial primary completion date
    |
    aspirin
    1m
    NVP: Naproxen Versus Placebo as Adjunct Treatment of Cellulitis: A Randomized Controlled Trial (clinicaltrials.gov)
    P3, N=884, Not yet recruiting, Ottawa Hospital Research Institute
    New P3 trial
    1m
    Effect of acetylsalicylic acid (ASA) pretreatment on white noise-induced stress model in rats. (PubMed, BMC Vet Res)
    These findings suggest that acetylsalicylic acid may influence selected oxidative stress-related parameters in specific brain regions following white noise exposure. However, the observed effects were limited and not consistent across all biochemical and inflammatory markers examined. Further studies are needed to clarify the optimal dose and duration of ASA treatment for controlling stress-related effects.
    Preclinical • Journal
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    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • CSF2 (Colony stimulating factor 2) • IL1B (Interleukin 1, beta) • IL4 (Interleukin 4)
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    aspirin