Colorectal cancer treatment is increasingly evolving into a precision oncology approach. Integration of molecular biomarkers enables tailored therapy decisions and opens new options, particularly in adjuvant and metastatic settings.

The prodrug of CPX, fosciclopirox, was evaluated for safety and preliminary efficacy in patients with advanced solid tumors, including bladder cancer, and was found to inhibit cell proliferation, the γ-secretase complex, and Notch signaling. Mechanistically, CPX modulates Notch1 activation temporally and reprograms T cell metabolism by limiting glycolysis, both of which impact proliferative and effector responses in activated T cells. Together, these findings identify CPX as a modulator of T cell immunity, highlighting the broader immunologic implications for its therapeutic application.

P=N/A, N=2641, Recruiting, IRCCS San Raffaele Roma | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

Sixty rats were separated into 4 groups structured as: control group; ulcerated group; Cana group; Omeprazole group. Additionally, it restored intestinal permeability, which, in turn, aggravated peptic ulcer via endotoxemia. Hence, Cana is a promising gastroprotective agent against peptic ulcers through multiple cascades, evidenced by network pharmacology and experimental validation.

P=N/A, N=112, Completed, Second Affiliated Hospital, School of Medicine, Zhejiang University | Recruiting --> Completed

P4, N=60, Completed, Kaohsiung Veterans General Hospital.

P2, N=426, Terminated, Fundació Institut Germans Trias i Pujol | Recruiting --> Terminated; The impact of the COVID-19 pandemic on TB diagnosis affected greatly the recruitment rate and posed challenges to the trial's timeline, consuming the funding needed to continue the enrolment.

Herein, we employ a fragment-based screening approach to identify four small-molecule ligands against the TopBP1 BRCT7-8 domain: adamantane acetic acid (ADA), zaltoprofen, diclofenac sodium, and quinine...Our NMR screening nominates orthosteric inhibitors, as well as quinine, a potential allosteric inhibitor. It shall also facilitate following structure-based design of more potent allosteric and orthosteric inhibitors of TopBP1.

P3, N=586, Not yet recruiting, The First Affiliated Hospital of Zhengzhou University

P=N/A, N=1000, Not yet recruiting, Massachusetts General Hospital

P=N/A, N=830, Completed, Geisinger Clinic | Active, not recruiting --> Completed

Aspirin chemoprevention was widely supported despite dose variability. These findings highlight opportunities for harmonization, gene-stratified precision prevention, and higher-quality prospective evidence to guide care.