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    DRUG:

    Consensi (amlodipine/celecoxib)

    i
    Other names: KIT 302
    Company:
    Burke Therap, Coeptis, Purple Biotech
    Drug class:
    COX2 inhibitor, Ca2+ channel antagonist
    Related drugs:
    8ms
    Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions. (PubMed, Genome Res)
    ESR1 chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples...Finally, in the TCGA breast cancer cohort, we can confirm these variations to associate with differences in expression for the target gene. Cumulatively, we reveal a natural hierarchy of ESR1-chromatin interactions in breast cancers within a highly heterogeneous inter-tumor ESR1 landscape, with the most common shared regions being most active and affected by germline functional risk SNPs for breast cancer development.
    Journal
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    ER (Estrogen receptor) • FOXA1 (Forkhead Box A1)
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    Consensi (amlodipine/celecoxib)