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    GENE:

    COMT (Catechol-O-Methyltransferase)

    i
    Other names: COMT, Catechol-O-Methyltransferase, Catechol O-Methyltransferase, Epididymis Secretory Sperm Binding Protein Li 98n, Testicular Tissue Protein Li 42, HEL-S-98n
    Associations

    News

    Trials
    28d
    Elucidating the mechanistic association of xylene inducing non-small cell lung cancer through network toxicology and molecular docking analysis. (PubMed, PLoS One)
    It also shows the usefulness of network toxicology in evaluating health risks from environmental chemicals. These findings may help guide future efforts in prevention and treatment strategies.
    Journal
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    ITGAM (Integrin, alpha M) • IL1A (Interleukin 1, alpha) • H3C1 (H3 Clustered Histone 1) • COMT (Catechol-O-Methyltransferase)
    1m
    Lu AF28996 in Participants With Parkinson's Disease (PD) (clinicaltrials.gov)
    P1, N=57, Completed, H. Lundbeck A/S | Active, not recruiting --> Completed
    Trial completion
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    COMT (Catechol-O-Methyltransferase)
    1m
    Molecular Effect of Tobacco on Genetic, Epigenetic, and Metabolic Pathways During Cancer Progression. (PubMed, Cureus)
    These findings underscore the need for targeted interventions, such as epigenetic therapies, metabolic reprogramming, and robust tobacco control policies, to mitigate the global burden of tobacco-related diseases. By providing a unified framework for understanding tobacco's molecular impact, this research advocates for precision medicine and public health strategies to address the pervasive effects of tobacco on human health.
    Review • Journal • PARP Biomarker • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • TERT (Telomerase Reverse Transcriptase) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • ATR (Ataxia telangiectasia and Rad3-related protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • MTHFR (Methylenetetrahydrofolate Reductase) • SOX2 • CASP3 (Caspase 3) • POU5F1 (POU Class 5 Homeobox 1) • CASP9 (Caspase 9) • HDAC1 (Histone Deacetylase 1) • YBX1 (Y-Box Binding Protein 1) • NANOG (Nanog Homeobox) • DRD2 (Dopamine Receptor D2) • SUV39H1 (SUV39H1 Histone Lysine Methyltransferase) • TCF4 (Transcription Factor 4) • COMT (Catechol-O-Methyltransferase)
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    TP53 mutation
    1m
    S-Methyl Thioester Formation Uncovers Early Biosynthetic Steps of Yatakemycin. (PubMed, Angew Chem Int Ed Engl)
    Notably, the catalytic mechanism of YtkW, an unprecedented thiocarboxylic acid S-MT, was elucidated via crystal structure determination, molecular docking, and relevant mutagenesis-based analyses. Based on these findings, a plausible early-stage biosynthetic pathway for YTM involving S-methyl thioester formation is proposed, which not only advances the biosynthetic understanding of YTM but also provides promising tools for exploring structural diversification of this antibiotic.
    Journal
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    COMT (Catechol-O-Methyltransferase)
    3ms
    Gold nanoparticle-mediated metabolic engineering in Trichoderma longibrachiatum MD33 unveils a hybrid terpenoid-alkaloid pathway for enhanced dendrobine biosynthesis. (PubMed, Microb Cell Fact)
    CH-AuNPs act as precision tools to upregulate dendrobine biosynthesis in T. longibrachiatum MD33, resolving the hybrid pathway and establishing this fungus as a sustainable production platform for dendrobine. The dose-dependent response highlights the dual role of nanoparticle-mediated engineering in metabolic enhancement and stress induction. This integration of nanotechnology and multi-omics bridges the critical gaps in fungal biotechnology, enabling scalable and eco-friendly alkaloid synthesis. Future applications include CRISPR-AuNP genome editing and bioreactor optimization, which will advance pharmaceutical and environmental biotechnologies.
    Journal
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    COMT (Catechol-O-Methyltransferase)
    3ms
    Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity-A Secondary Analysis of a Randomized Controlled Trial. (PubMed, Nutrients)
    The COMT genotype did not modify the effects of GTE supplementation on inflammatory cytokines. Future studies with a larger sample size among those at high risk of systemic inflammation are warranted.
    Clinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CRP (C-reactive protein) • COMT (Catechol-O-Methyltransferase)
    3ms
    Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking. (PubMed, Neuroprotection)
    Molecular docking confirmed strong binding affinity between isoflurane and core targets (e.g., CASP3: affinity-5.54 kcal/mol), highlighting dopaminergic disruption and apoptotic activation. This study elucidates isoflurane's multi-target neurotoxicity in POD, providing a mechanistic foundation for mitigating postoperative neurological complications.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3) • SLC6A3 (Solute Carrier Family 6 Member 3) • COMT (Catechol-O-Methyltransferase)
    3ms
    Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult-A Systematic Review. (PubMed, Brain Behav)
    This systematic review suggests that APOE-ε4 and potentially the G allele of COMT rs4680 are associated with poor cognitive outcomes following brain insults. The type of brain injury does not appear to influence whether genetic variants predispose to favorable or unfavorable cognitive outcomes. Future research may benefit from focusing on these markers, particularly in larger datasets, to validate these findings.
    Review • Journal
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    APOE (Apolipoprotein E) • BDNF (Brain Derived Neurotrophic Factor) • COMT (Catechol-O-Methyltransferase)
    4ms
    Genetics of Chronic Shoulder Pain/Disability in South African Breast Cancer Survivors: Polygenic Contributions by Opioid and Pain Signaling Pathways. (PubMed, OMICS)
    Collectively, these findings suggest that chronic shoulder pain/disability in breast cancer survivors in this sample of South African patients is influenced by the combined effects of polymorphisms within the ABCB1-OPRM1-COMT genes. These observations present the potential for further translational research, personalized medicine, and pain management strategies to improve the long-term quality of life in breast cancer patients.
    Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • OPRM1 (Opioid Receptor Mu 1) • COMT (Catechol-O-Methyltransferase)
    4ms
    A potentially dangerous case of mistaken identity: giant asymptomatic composite phaeochromocytoma. (PubMed, Endocrinol Diabetes Metab Case Rep)
    Measurement of metanephrine and normetanephrine levels in plasma or urine is the preferred biochemical investigation for PCC. Composite PCC are rare but have a similar clinical presentation and management to other PCC.
    Journal
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    COMT (Catechol-O-Methyltransferase)
    5ms
    Investigating the Trajectories of Association Between Biomarkers and Cancer-Related Cognitive Impairment in Patients with Breast Cancer: A Systematic Review. (PubMed, Cancers (Basel))
    Evidence for biomarker correlates of CRCI in BC is highly heterogeneous. Longitudinal, harmonized, and treatment-specific studies are needed to establish reproducible biomarker panels for risk stratification and targeted intervention.
    Review • Journal • IO biomarker
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • APOE (Apolipoprotein E) • BDNF (Brain Derived Neurotrophic Factor) • COMT (Catechol-O-Methyltransferase)
    5ms
    Novel Genetic Susceptibility Markers for Breast Cancer in Iraqi Women: First Evidence of CYP3A4*1B Protective Effects and GSTP1/MTHFR Risk Associations. (PubMed, Clin Breast Cancer)
    The study presented the taw evidence of both CYP3A4*1B and GSTP1 Ile105Val along with MTHFR C677T polymorphisms associating them to breast cancer susceptibility in Iraqi population which reflects these specific genetic risks and reinforces middle eastern populations towards precision medicine frameworks concerning breast cancer treatment and intervention strategies.
    Journal
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    GSTP1 (Glutathione S-transferase pi 1) • MTHFR (Methylenetetrahydrofolate Reductase) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • COMT (Catechol-O-Methyltransferase)