COMT (Catechol-O-Methyltransferase)

CH-AuNPs act as precision tools to upregulate dendrobine biosynthesis in T. longibrachiatum MD33, resolving the hybrid pathway and establishing this fungus as a sustainable production platform for dendrobine. The dose-dependent response highlights the dual role of nanoparticle-mediated engineering in metabolic enhancement and stress induction. This integration of nanotechnology and multi-omics bridges the critical gaps in fungal biotechnology, enabling scalable and eco-friendly alkaloid synthesis. Future applications include CRISPR-AuNP genome editing and bioreactor optimization, which will advance pharmaceutical and environmental biotechnologies.

The COMT genotype did not modify the effects of GTE supplementation on inflammatory cytokines. Future studies with a larger sample size among those at high risk of systemic inflammation are warranted.

Molecular docking confirmed strong binding affinity between isoflurane and core targets (e.g., CASP3: affinity-5.54 kcal/mol), highlighting dopaminergic disruption and apoptotic activation. This study elucidates isoflurane's multi-target neurotoxicity in POD, providing a mechanistic foundation for mitigating postoperative neurological complications.

This systematic review suggests that APOE-ε4 and potentially the G allele of COMT rs4680 are associated with poor cognitive outcomes following brain insults. The type of brain injury does not appear to influence whether genetic variants predispose to favorable or unfavorable cognitive outcomes. Future research may benefit from focusing on these markers, particularly in larger datasets, to validate these findings.

Collectively, these findings suggest that chronic shoulder pain/disability in breast cancer survivors in this sample of South African patients is influenced by the combined effects of polymorphisms within the ABCB1-OPRM1-COMT genes. These observations present the potential for further translational research, personalized medicine, and pain management strategies to improve the long-term quality of life in breast cancer patients.

Measurement of metanephrine and normetanephrine levels in plasma or urine is the preferred biochemical investigation for PCC. Composite PCC are rare but have a similar clinical presentation and management to other PCC.

Evidence for biomarker correlates of CRCI in BC is highly heterogeneous. Longitudinal, harmonized, and treatment-specific studies are needed to establish reproducible biomarker panels for risk stratification and targeted intervention.

The study presented the taw evidence of both CYP3A4*1B and GSTP1 Ile105Val along with MTHFR C677T polymorphisms associating them to breast cancer susceptibility in Iraqi population which reflects these specific genetic risks and reinforces middle eastern populations towards precision medicine frameworks concerning breast cancer treatment and intervention strategies.

Genetic polymorphisms and immune dysregulation contribute to FM-DED pathophysiology, supporting the need for differentiated diagnosis and targeted therapies.

These findings suggest a possible role for these polymorphisms in ovarian cancer risk and highlight the need for further studies. This review was registered in PROSPERO (CRD42023464116).

Substantial uncertainty remains within the evidence of genetic factors for the selected late effects after childhood cancer. International collaborations, methodological and reporting harmonization, and prioritization of replication and functional validation should help future research to be more consistent, create more robust findings, and bridge the gap between research and clinical practice.

Our data suggests that the use of EE/DRSP increases the flux of endogenous hormones into the hormone biotransformation pathway, resulting in increased conversion of estrogens (especially E1) into conjugated, catechol, and methylated estrogens but that the latter is limited by methyl-group donor availability. Interestingly, the increased oxidation of estrogens in COC users does not result in increased DNA-adduct formation.