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    DRUG:

    Compound E

    i
    Other names: Compound E, γ-secretase inhibitor XXI, gamma-secretase inhibitor XXI, GSI-XXI
    Company:
    Beijing Normal University, Southeast University, University of Brescia Medical School
    Drug class:
    γ-secretase inhibitor
    Related drugs:
    6ms
    Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression. (PubMed, Discov Oncol)
    Celastrol inhibits the function of B16-F10 cells by inhibiting the PI3K/AKT/mTOR cellular pathway and regulating the expression of downstream HIF-α mRNA.
    Preclinical • Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    |
    Compound E
    over1year
    Evidence-based identification of breast cancer and associated ovarian and uterus cancer risk components in source waters from high incidence area in the Pearl River Basin, China. (PubMed, Sci Total Environ)
    Moreover, these identified water components were present at levels comparable to other regions with high female cancer prevalence, suggesting that the potential risk of these components may not be exclusive to the study region. Together, multiple levels of evidence suggested that long-term co-exposures to source water estrogenic components may be important to the development of breast, ovarian, and uterus cancers.
    Journal
    |
    ER (Estrogen receptor)
    |
    Compound E