Colorectal Cancer

P=N/A, N=100000, Active, not recruiting, Institut National de la Santé Et de la Recherche Médicale, France | Trial completion date: Dec 2025 --> Dec 2046

P=N/A, N=400, Enrolling by invitation, Indiana University | Trial completion date: Jul 2026 --> Dec 2026 | Trial primary completion date: Apr 2026 --> Dec 2026

P2, N=76, Recruiting, Sixth Affiliated Hospital, Sun Yat-sen University

Our ML approach accurately predicted MSI status in colorectal and uterine cancers using multiomics data derived from NGS, without relying on direct microsatellite sequencing. The ability to identify MSI-high tumors among indeterminate cases demonstrates potential to improve diagnostic precision and ensures timely access to immunotherapy for patients with MSI-high disease.

At the beginning, hypoxia caused an alteration in the anti-colorectal-cancer activity of NaB, which then returned to normal. Our data revealed the novel finding that NaB downregulates CA IX, suggesting a potential therapeutic strategy for colorectal cancer that targets tumor metabolism and pH regulation.

Overall, CAPE and D₂O may be an effective adjuvant for enhancing therapeutic efficacy in colon cancer. However, further research is needed to determine whether their synergistic effects are also selective in other malignancies, as well as with their toxicokinetic potential.

In conclusion, chronic H. pylori infection may contribute to CRC pathogenesis through sustained inflammation and genetic dysregulation. The study highlights TIMP3 suppression as a potential factor in CRC progression, warranting further investigation into its clinical implications.

Lower DPD and MTHFR expression predicts a favorable response to neoadjuvant CAPEOX in advanced CRC. These biomarkers offer a promising, non-invasive approach to personalizing treatment strategies potentially enhancing therapeutic efficacy while minimizing unnecessary toxicity.

Our study suggests that vitamin D3 enhances fluoropyrimidine efficacy in metastatic CRC patients by modulating angiogenesis and proliferation pathways, supporting its potential as a safe, low-cost adjunct to chemotherapy.

By combining simplicity, reproducibility, and minimal computational overhead, the present pipeline provides an accessible framework for targeted transcriptomic analysis of long-read sequencing data. It may facilitate adoption of ONT-based transcriptomic profiling in settings with restricted computational resources.

The differential apoptotic response between HCC1937 and HCT116 cells suggests cell-type-specific mechanisms. These findings extend the known anti-tumor activity spectrum of AI-discovered red algal lectin Siye and provide a basis for further investigation of its glycan-associated cellular effects and marine drug discovery potential.

The NII may serve as an exploratory indicator of the chronic inflammation-nutrition imbalance in these patients, and it may offer modest added value for risk stratification and individualized management. Further large-scale, multicenter prospective studies are warranted to validate these findings.