Colon Cancer

P=N/A, N=170, Recruiting, Gustave Roussy, Cancer Campus, Grand Paris | Not yet recruiting --> Recruiting | Trial completion date: Aug 2027 --> Mar 2028 | Trial primary completion date: Apr 2027 --> Sep 2027

P=N/A, N=820, Recruiting, Georgetown University | Not yet recruiting --> Recruiting

P=N/A, N=300, Not yet recruiting, Assistance Publique - Hôpitaux de Paris

This exploratory analysis suggested a higher uptake of risk-reducing surgery at the safety-net hospital than at the university medical center. Understanding factors contributing to this difference will be critical to supporting gynecologic cancer risk management in Lynch syndrome.

Our findings demonstrate a novel pathway by which FAT10 activates autophagy by stabilizing ATG3, leading to ZO-1 degradation and promoting CC lung metastasis. This study provides new insights into the role of FAT10 in regulating protein homeostasis and offers a potential strategy for targeting the FAT10-ATG3-autophagy axis in the treatment of CC metastasis.

Analysis of CRC patient data revealed that the metastatic gene signature associated with the MAPK-high-WNT-low state correlated with poorer survival outcomes. These findings underscore the plasticity of metastasis-initiating cells in CRC driven by the opposing roles of MAPK and WNT signaling, despite their synergy observed during colon tumorigenesis.

P=N/A, N=145, Recruiting, Aalborg University Hospital

Notably, it remodeled the tumor immune microenvironment by promoting CD8⁺ T cell infiltration, enhancing the secretion of IFN-γ and TNF-α, and reducing the populations of regulatory T cells and myeloid-derived suppressor cells. Mn3O4/QD@LM confirms the synergistic role of multi-enzyme activities and STING pathway activation in potentiating sonodynamic immunotherapy, and provides an innovative strategy to overcome TME-mediated therapy resistance.

RCC was associated with a higher rate of dMMR and high-grade tumours, and a greater proportion of mucinous adenocarcinomas.

Mutational signatures in cancers can result in part from non-rare germline variation in DNA repair. The specific effect of MUTYH heterozygosity on CRC risk plausibly reflects the high baseline levels of oxidative damage and SBS18 activity in the colorectum.

P=N/A, N=180, Recruiting, Unity Health Toronto | Not yet recruiting --> Recruiting