Colon Cancer

P=N/A, N=10, Active, not recruiting, University College, London | Recruiting --> Active, not recruiting

Treatment included glucocorticoids, plasmapheresis, and azathioprine, followed by right hemicolectomy and adjuvant CAPEOX chemotherapy...The temporal relationship and improvement with cancer-directed therapy raise the possibility that malignancy may act as a trigger for clinically overt vasculitis. Recognition of this relationship may help guide appropriate management and avoid unnecessary or prolonged immunosuppression.

P=N/A, N=70, Recruiting, University Hospital, Montpellier | Trial completion date: Oct 2028 --> Oct 2033 | Trial primary completion date: Oct 2025 --> Apr 2027

This study is the first to examine p27 localization in WT KRAS CRC. The observed association between WT KRAS expression and cytoplasmic p27 localization highlights a potential mechanism contributing to tumour progression through altered p27 function.

We also observed a modulation of endoplasmic reticulum stress response, in particular decreased levels of ATF6, in LCS-knockdown cells treated with oxaliplatin. The present findings support the functional role of LCS in regulating the chemosensitivity of colon cancer cells towards the action of chemotherapy drugs, such as oxaliplatin, with possible further implications for the mechanisms underlying toxic action of platinum-based drugs in cancer cells.

Immunohistochemical analysis showed positivity for CK7, CK19, EMA, and trypsin, and negativity for mesothelial, enteric, and lymphatic markers, thereby excluding the subtypes described in current classifications. This exceptional finding, not previously reported, broadens the histopathological spectrum of mesenteric cysts and suggests pancreatic heterotopia as a possible origin of a subtype not recognised to date.

Meanwhile, glucose starvation induces CPT1A-mediated succinylation of FH at residues K66/K80, reducing FH protein stability and promoting its degradation via the autophagy-lysosome pathway. Our findings reveal the critical role of FH and its succinylation in CRC cell adaptation to glucose starvation, inhibiting ferroptosis, and maintaining cancer cell proliferation, providing novel potential targets and a theoretical basis for the clinical treatment of CRC.

Our results demonstrate that tumour sidedness critically influences liquid biopsy interpretation in metastatic colorectal cancer, underscoring the need to incorporate the primary tumour location into the clinical assessment of circulating biomarkers.

P=N/A, N=50, Not yet recruiting, Peking University Cancer Hospital & Institute

This study demonstrates that the combination of 3M-052 and the anti-TNFR2 antibody exerts a synergistic effect, effectively inhibiting CRC progression and inducing long-term immune memory. Overall, these findings support the view that MT combination therapy represents a potentially effective strategy.

These findings demonstrate that TAMpep-IP reprograms the immunosuppressive TME by selectively suppressing STAT6 signaling in M2 TAMs, thereby restoring cytotoxic T-cell activity and inhibiting tumor progression. This selective strategy offers a promising therapeutic avenue to overcome TAM-mediated immune suppression and enhance the efficacy of existing immunotherapies.

Biological evaluation identified the indomethacin-conjugated derivative 7a as a lead candidate that self-assembles into nanoscale structures and selectively accumulates in the mitochondria of HCT-116 colon cancer cells...This mitochondrial damage triggers apoptosis via inhibition of Bcl-2, Cas-3/9, PARP and Cox-2, as well as upregulation of BAX, alongside inducible autophagy that can be pharmacologically regulated. This heptamethine cyanine-NSAID conjugate establishes a versatile mitochondria-targeted chemo-phototherapeutic system and advances light-activated organelle-directed chemical biology as a promising strategy for minimally invasive cancer therapy.