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    GENE:

    COL3A1 (Collagen Type III Alpha 1 Chain)

    i
    Other names: COL3A1, Collagen Type III Alpha 1 Chain, Ehlers-Danlos Syndrome Type IV, Autosomal Dominant, Collagen, Type III, Alpha 1, Collagen Alpha-1(III) Chain, EDS4A, Alpha-1 Type III Collagen, Alpha1 (III) Collagen, Collagen, Fetal, EDSVASC, PMGEDSV
    8d
    Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level. (PubMed, Hepatology)
    We revealed the key biological mechanisms involved in the invasion and colonization phases of iCCA liver metastasis. Moreover, we provide valuable data for understanding iCCA liver metastasis and a possible avenue for the treatment of advanced iCCA.
    Journal
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    COL3A1 (Collagen Type III Alpha 1 Chain)
    20d
    Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma. (PubMed, Cell Signal)
    In conclusion, CCL11 over-production drives HSC activation, creating an ECM-disorganized and immunosuppressive TME via the CCL11/CCR3 axis in LEN-treated HCC. Combination therapy with CCR3 inhibitor and LEN might represent a novel therapeutic strategy.
    Journal
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    S100A9 (S100 Calcium Binding Protein A9) • CCL11 (C-C Motif Chemokine Ligand 11) • COL3A1 (Collagen Type III Alpha 1 Chain) • MRC1 (Mannose Receptor C-Type 1) • CCR3 (C-C Motif Chemokine Receptor 3)
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    Lenvima (lenvatinib)
    27d
    BNC2 as a novel driver of pancreatic cancer progression through transcriptional regulation of COL3A1 and epithelial-to-mesenchymal transition. (PubMed, Med Oncol)
    Knockdown of BNC2 suppresses EMT, reduces invasiveness, and downregulates COL3A1, whereas COL3A1 overexpression rescues these effects, establishing the BNC2-COL3A1 axis as a critical driver of tumor progression. These findings highlight BNC2 as a potential biomarker and therapeutic target in pancreatic cancer, offering new insights into the molecular mechanisms underlying this aggressive disease.
    Journal
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    COL3A1 (Collagen Type III Alpha 1 Chain) • BNC1 (Basonuclin 1)
    2ms
    Novel Finding of PLAG1 Overexpression and COL3A1::PLAG1 Rearrangement in Nevus Lipomatosus Superficialis. (PubMed, Pediatr Dev Pathol)
    Ancillary molecular testing by RNA fusion panel showed COL3A1::PLAG1 rearrangement. These findings suggest that some cases of NLS may share genetic alterations with neoplastic processes involving PLAG1 rearrangements.
    Journal
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    COL3A1 (Collagen Type III Alpha 1 Chain) • PLAG1 (PLAG1 Zinc Finger)
    2ms
    Modeling hepatic fibrosis in TP53 knockout iPSC-derived human liver organoids. (PubMed, Mol Oncol)
    This model provides a valuable platform for exploring the role of key driver genes, such as TP53, in the initiation and progression of fibrosis, enabling the study of hepatic progenitor cell transformation across diverse microenvironmental contexts. As such, it holds the potential for advancing early stage drug discovery and the identification of novel therapeutic targets for the treatment of liver fibrosis.
    Journal
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    TP53 (Tumor protein P53) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • MUC1 (Mucin 1) • GPC3 (Glypican 3) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • COL11A1 (Collagen Type XI Alpha 1 Chain)
    2ms
    An Integrative Genotyping and Gene Expression Profiling of the Mutated Human FAM111B Gene and Fibrosis-Associated Pathway in the POIKTMP Syndrome. (PubMed, J Cell Mol Med)
    These findings suggest that FAM111B mutations drive fibrosis through dysregulated gene networks, highlighting potential therapeutic targets for POIKTMP and related fibrotic diseases. Further research is required to understand FAM111B's role in fibrosis fully.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • PDGFA (Platelet Derived Growth Factor Subunit A) • COL3A1 (Collagen Type III Alpha 1 Chain) • THBS2 (Thrombospondin 2) • CTGF (Connective tissue growth factor) • ITGB1 (Integrin Subunit Beta 1)
    3ms
    Beneficial Effects of Different Types of Exercise on Diabetic Cardiomyopathy. (PubMed, Biomolecules)
    In addition, all three exercise modalities effectively suppressed the aberrant activation of the cGAS-STING signaling pathway in the myocardium. In conclusion, exercise training exerts beneficial effects against DCM by improving cardiac function and reducing inflammation, PANoptosis, and fibrosis, and HIIT emerged as the most effective strategy.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CCL2 (Chemokine (C-C motif) ligand 2) • TGFB1 (Transforming Growth Factor Beta 1) • COL3A1 (Collagen Type III Alpha 1 Chain)
    3ms
    Angiogenesis-Related Genes Predict Outcomes and Immune Traits in Skin Melanoma. (PubMed, Int J Mol Sci)
    The study underscores the prognostic relevance of ARGs in skin melanoma and their contribution to tumor immunity. Overall, our findings expand our understanding of melanoma immunogenetics, suggesting the use of angiogenesis-related genes not merely as vascular regulators, but also as immune modulators.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • COL5A2 (Collagen Type V Alpha 2 Chain) • PTK2 (Protein Tyrosine Kinase 2) • S100A4 (S100 calcium binding protein A4)
    3ms
    In silico framework about prediction of collagen-derived matrikine generation and its ligand function binding to integrin [Formula: see text] for malignancy of colon cancer. (PubMed, In Silico Pharmacol)
    Given the integrin [Formula: see text] as the well-known cell-surface marker of the phagocytic cells, our study suggests targeting the proposed candidates for immunotherapy during the colon cancer metastasis. The online version contains supplementary material available at 10.1007/s40203-025-00417-2.
    Journal • IO biomarker
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    ICAM1 (Intercellular adhesion molecule 1) • ITGAM (Integrin, alpha M) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • MMP14 (Matrix Metallopeptidase 14)
    4ms
    Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. (PubMed, Front Oncol)
    We identified some differentially expressed genes relevant to oncogenic signaling and immunosuppressive tumor-associated macrophages. These findings provide novel insights into factors affecting prognosis in patients with residual disease after NAC for early-stage TNBC.
    Journal
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    ACTA2 (Actin Alpha 2 Smooth Muscle) • S100A9 (S100 Calcium Binding Protein A9) • CHI3L1 (Chitinase 3-like 1) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • KRT14 (Keratin 14) • COL3A1 (Collagen Type III Alpha 1 Chain) • IFI27 (Interferon Alpha Inducible Protein 27) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • MMP7 (Matrix metallopeptidase 7) • MYLK (Myosin Light Chain Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) • SERPINA3 (Serpin Family A Member 3) • TPM2 (Tropomyosin 2) • RPL22 (Ribosomal Protein L22)
    4ms
    A Validated Proteomic Signature of Basal-like Triple-Negative Breast Cancer Subtypes Obtained from Publicly Available Data. (PubMed, Cancers (Basel))
    These findings suggest the existence of novel molecular signatures that could improve TNBC classification, prognosis, and potential therapeutic targeting.
    Journal
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    COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • TUBA1C (Tubulin Alpha 1c) • COL11A1 (Collagen Type XI Alpha 1 Chain) • SNRNP70 (Small Nuclear Ribonucleoprotein U1 Subunit 70)