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    GENE:

    COL14A1 (Collagen Type XIV Alpha 1 Chain)

    i
    Other names: COL14A1, Collagen Type XIV Alpha 1 Chain, UND, Collagen, Type XIV, Alpha 1, Collagen Alpha-1(XIV) Chain, Undulin, Undulin (Fibronectin-Tenascin-Related)
    Associations

    News

    Trials
    7ms
    Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer. (PubMed, Discov Oncol)
    We developed a favorable prognostic model using collagen genes, which are potential biomarkers for forecasting the prognosis of BCa.
    Journal • Tumor mutational burden • Gene Signature
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    TMB (Tumor Mutational Burden) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • COL4A1 (Collagen Type IV Alpha 1 Chain)
    7ms
    Koumine alters immune barrier function by targeting TGFβ-mediated collagen deposition in gastric cancer. (PubMed, Eur J Pharmacol)
    Furthermore, the combination of Koumine with anti-PD1 immune checkpoint inhibitor generated synergistic effects in immune-competent GC mouse models, enhancing CD8+ T-cell infiltration and significantly inhibiting tumor growth. The results of our study suggest that Koumine is a potent agent that may be used to disrupt immune exclusion and optimize immunotherapy in patients with GC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
    8ms
    Integrative Machine Learning and Bioinformatics Approach for Identifying Key Biomarkers in Gallbladder Cancer Diagnosis and Progression. (PubMed, IET Syst Biol)
    The study highlights NTRK2, COL14A1, SCN4B, ATP1A2, SLC17A7, SLIT3, COL7A1, CLDN4, CLEC3B, ADCYAP1R1 and MFAP4 as crucial genes associated with GBC. SLIT3, COL7A1 and CLDN4 serve as highly predictive biomarkers, and findings can improve early diagnosis and prognosis, aiding clinical decision-making.
    Journal
    |
    NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1) • CLEC3B (C-Type Lectin Domain Family 3 Member B) • COL14A1 (Collagen Type XIV Alpha 1 Chain)
    over1year
    Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin-Positive Giant Cell Tumor. (PubMed, Genes Chromosomes Cancer)
    Recent studies demonstrated a recurrent HMGA2::NCOR2 fusion in many cases. We herein describe a case of XGET/KP-GCT arising in the right femoral head of a 19-year-old male harboring a rare novel HMGA2::COL14A1 fusion.
    Journal
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    NCOR2 (Nuclear Receptor Corepressor 2) • HMGA2 (High mobility group AT-hook 2) • COL14A1 (Collagen Type XIV Alpha 1 Chain)
    over1year
    Evaluation of a Proteomics-Guided Protein Signature for Breast Cancer Detection in Breast Tissue. (PubMed, J Proteome Res)
    Upon stratifying, to solely include the Basal-Like/Triple-Negative subtype, the ROC AUC increased to 0.922-0.959 with predictive accuracy of 84.2%-89%. These findings suggest a potential role for the identified signature in distinguishing cancerous from noncancerous breast tissue, offering insights into enhancing diagnostic accuracy.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • COL14A1 (Collagen Type XIV Alpha 1 Chain)
    over1year
    Clinical Significance and Molecular Annotation for PD-L1 Negative Advanced Non-Small Cell Lung Cancer with Sensitivity to Responsive to Dual PD-1/CTLA-4 Blockade. (PubMed, Immunotargets Ther)
    ERBB4 and PCSK5 mutation could serve as predictive biomarkers for patients with Anti-PD-(L)1+Anti-CTLA-4 combination therapy. Our systematic nomogram demonstrates significant potential in predicting the prognosis for NSCLC patients with responsive to dual PD-1/CTLA-4 blockade.
    Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
    |
    PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • LTBP1 (Latent-transforming growth factor beta-binding protein 1) • ANO1 (Anoctamin 1) • COL14A1 (Collagen Type XIV Alpha 1 Chain)
    |
    PD-L1 expression • KRAS mutation • PD-L1 negative
    over1year
    Integrating single-cell and spatial transcriptomic analysis to unveil heterogeneity in high-grade serous ovarian cancer. (PubMed, Front Immunol)
    The therapeutic targeting of this metabolic pathway with existing inhibitors appears promising in curbing tumor proliferation. These findings enhance our understanding of HGSOC heterogeneity and reveal potential therapeutic targets, promising more effective management strategies for this aggressive cancer subtype.
    Journal
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    CD8 (cluster of differentiation 8) • COL14A1 (Collagen Type XIV Alpha 1 Chain)
    over1year
    CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy. (PubMed, Int J Mol Sci)
    Recently, it was found that the unique metabolism of CAFs can be targeted to prevent PDAC progression, where PDAC cells utilize glucose, whereas CAFs in turn utilize lactate, which may be epigenetically regulated, mediated by its target genes including CXCR4. In summary, CAFs have unique molecular characteristics, which have been rigorously clarified as novel therapeutic targets of PDAC progression.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • IL6 (Interleukin 6) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3) • TGFB1 (Transforming Growth Factor Beta 1) • LRRC1 (Leucine Rich Repeat Containing 1) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • POSTN (Periostin)
    almost2years
    Review of Patient Gene Profiles Obtained through a Non-Negative Matrix Factorization-Based Framework to Determine the Role Inflammation Plays in Neuroblastoma Pathogenesis. (PubMed, Int J Mol Sci)
    Eighty-eight gene profiles were selected and analyzed using a non-negative matrix factorization framework to extract a subset of genes relevant to the identification of an inflammatory phenotype, whose targets (PIK3CG, NFATC2, PIK3R2, VAV1, RAC2, COL6A2, COL6A3, COL12A1, COL14A1, ITGAL, ITGB7, FOS, PTGS2, PTPRC, ITPR3) allow further investigation. Based on the genetic signals automatically derived from the data used, neuroblastoma could be classified according to stage rather than as a "cold" or "poorly immunogenic" tumor.
    Review • Journal
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    PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • COL6A3 (Collagen Type VI Alpha 3 Chain) • VAV1 (Vav Guanine Nucleotide Exchange Factor 1) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • COL6A2 (Collagen Type VI Alpha 2 Chain) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2 ) • RAC2 (Rac Family Small GTPase 2)
    2years
    Identification of tumor-suppressor genes in lung squamous cell carcinoma through integrated bioinformatics analyses. (PubMed, Oncol Res)
    Two LUSC cell lines were used to validate the functions of CHRDL1 and FAM107A through overexpression experiment. Together, our data revealed novel candidate tumor-suppressor genes in LUSC, suggesting previously unappreciated mechanisms in the progression of LUSC.
    Journal
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    COL14A1 (Collagen Type XIV Alpha 1 Chain) • FGF7 (Fibroblast Growth Factor 7)
    2years
    The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer-associated fibroblast subtypes. (PubMed, J Pathol)
    © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
    Journal
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    COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • COL6A1 (Collagen Type VI Alpha 1 Chain) • COL11A1 (Collagen Type XI Alpha 1 Chain) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • COL5A1 (Collagen Type V Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain)
    over2years
    Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma. (PubMed, Cancer Lett)
    A high circ-CDYL level is caused by HIF-1⍺-mediated transcriptional upregulation of its parental gene CDYL and splicing factor EIF4A3 under a hypoxia microenvironment. Hence, the hypoxia microenvironment enables the high-tendency lung metastasis of ICAM-1 CCSCs through the HIF-1⍺/circ-CDYL-EEF1A2/COL14A1 axis, potentially allowing clinicians to preoperatively detect ICAM-1 CCSCs as a real-time biomarker for precisely deciding HCC treatment strategies.
    Journal • Cancer stem
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • ICAM1 (Intercellular adhesion molecule 1) • COL14A1 (Collagen Type XIV Alpha 1 Chain) • EIF4A3 (Eukaryotic Translation Initiation Factor 4A3)