CNTN1 (Contactin 1)

Further co-localisation analysis revealed that ADAMTS5, GNLY and PCSK7 shared genetic variants associated with the risk of malignant neoplasms of bone and articular cartilage. Molecular docking analysis indicated that compounds such as aspirin and vitamin E exhibited low binding energies with GNLY, PCSK7 and ADAMTS5, suggesting potential therapeutic intervention opportunities.ConclusionThis study identified three proteins (GNLY, PCSK7 and ADAMTS5) associated with a high risk of malignant neoplasms of bone and articular cartilage through Mendelian randomisation and co-localisation analyses, providing novel molecular evidence for early diagnosis, risk assessment and potential targeted therapies for malignant neoplasms of bone and articular cartilage.

P=N/A, N=1550, Not yet recruiting, Tongji Hospital | Trial completion date: Mar 2032 --> Mar 2037 | Trial primary completion date: Mar 2030 --> Mar 2036

P=N/A, N=1550, Not yet recruiting, Tongji Hospital

Summarizing, we described numerous potential therapeutic targets, suggesting patients with MDM2-amplified tumors could potentially benefit from, exemplary, Mitogen-activated protein kinase kinase inhibitors or tryptophan metabolism inhibitors in new combinational treatment regimens. Future mechanistic studies are needed to validate these findings.

Furthermore, immunohistochemical staining showed consistent protein-level changes in MMP11 and PYGL. These results illuminate the potential for a transcriptomic biomarker to differentiate benign from malignant melanocytic neoplasms and improve the accuracy of melanoma diagnosis.

Thymoma can be accompanied by anti-CNTN1 AN. Adequate immunotherapies should be considered regardless of the efficacy of thymectomy.

Notably, PSEN1 overexpression reversed the impaired proliferation, migration, and invasion induced by CNTN1 suppression. These findings suggest that CNTN1 promotes OC progression through PSEN1 regulation and may represent a prognostic biomarker for OC.

Overexpression of CNTN1 reversed the inhibitory effects of PFKM knockdown on GC progression. Our research showed that increasing PFKM levels accelerated GC development by regulating CNTN1 expression through mechanisms involving histone lactylation, which could potentially contribute to novel approaches in diagnosing and treating GC.

Salvianolic acid B, an inhibitor of CLDN4, is demonstrated to reduce both HBT and lenvatinib resistance in HCC. Additionally, combination chemotherapy appears to be an effective therapeutic strategy for HCC patients undergoing HBT.

Neurotransmitters including epinephrine, norepinephrine, dopamine, serotonin, and acetylcholine precisely regulate critical pathways such as AKT/mTOR, ERK, and NF-κB, thereby driving malignant cell behaviors, immune evasion, and chemoresistance...Additionally, neural-associated biomarkers like NEDD9, CNTN1, and nerve growth factor (NGF) exhibit prognostic significance, supporting their future clinical application. By systematically integrating neuroscience with oncology, this review identifies innovative neural-based therapeutic strategies, highlights key mechanistic insights, and outlines promising directions for future research and personalized clinical management of HCC.

These novel miR-mRNA interaction networks identified dysregulated pathways not observed when assessing mRNA alone and provide a foundation for further investigation of their utility as diagnostic and predictive biomarkers.