CLPTM1L expression

CLPTM1L could impact cervical cancer cell proliferation and cisplatin-induced cell apoptosis, as well as cisplatin susceptibility in cervical cancer cells. This investigation has bestowed upon us novel insights into the pathogenesis of cervical cancer, underscoring the potential of CLPTM1L as a promising target for chemotherapeutic sensitization in the management of this malignancy.

Introduction: We examined the correlation between CLPTM1L (Cleft lip and palate transmembrane protein 1-like) expression and recurrence of intermediate- and high-risk stage IB-IIB (FIGO2008) cervical cancer undergoing radical hysterectomy followed by TP (paclitaxel plus cisplatin). The expression of CLPTM1L was significantly higher in group B than in group A (p<0.001). Cases were divided into two groups; low CLPTM1L expression group (weighted score≤4, n=59), and high CLPTM1L expression group (weighted score≥6, n=32). High CLPTM1L expression group was more likely to recur after adjuvant TP than low expression group (p<0.01).