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    GENE:

    CLHC1 (Clathrin Heavy Chain Linker Domain Containing 1)

    i
    Other names: CLHC1, Clathrin Heavy Chain Linker Domain Containing 1, C2orf63, Clathrin Heavy Chain Linker Domain-Containing Protein 1, FLJ31438, Chromosome 2 Open Reading Frame 63
    Associations

    News

    Trials
    almost3years
    High-Throughput Sequencing Reveals That Rotundine Inhibits Colorectal Cancer by Regulating Prognosis-Related Genes. (PubMed, J Pers Med)
    Rotundine inhibits the development and progression of colorectal cancer by regulating the expression of these prognosis-related genes. Our findings could further provide new directions for the treatment of colorectal cancer.
    Journal
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    CLHC1 (Clathrin Heavy Chain Linker Domain Containing 1) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3)
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    Rotundine (levo-tetrahydropalmatine)
    almost4years
    Effective treatment in lung adenocarcinoma patient with brain metastases harboring novel CLHC1/RNT4 intergenic region- ALK fusion: A case report. (PubMed, Medicine (Baltimore))
    ALK fusion is a risk factor for brain metastasis (BM) in patients with advanced non-small NSCLC patients. In our case, a novel CLHC1/RNT4 intergenic region, ALK fusion, was identified for the first time in a lung adenocarcinoma patient with BM, who benefited from crizotinib and endostar sequential alectinib. Our case highlights the advantages of NGS for fusion detection and provides promising treatment options for NSCLC patients with BM harboring ALK fusions.
    Journal
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    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • CLHC1 (Clathrin Heavy Chain Linker Domain Containing 1)
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    ALK fusion
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    Xalkori (crizotinib) • Alecensa (alectinib) • Endostar (recombinant human endostatin)