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    GENE:

    CLEC7A (C-Type Lectin Domain Containing 7A)

    i
    Other names: CLEC7A, C-Type Lectin Domain Containing 7A, C-Type Lectin Domain Family 7 Member A, Dectin-1, C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12, C-Type Lectin Superfamily Member 12, DC-Associated C-Type Lectin 1, Beta-Glucan Receptor, CLECSF12, DECTIN1, SCARE2, CD369, BGR, Dendritic Cell-Associated C-Type Lectin-1, Dendritic Cell-Associated C-Type Lectin 1, C-Type Lectin Domain Family 7, Member A, Lectin-Like Receptor 1, CD369 Antigen, HDectin-1, CANDF4
    24d
    Algal β-glucan: Structure, immunomodulatory effects and application prospects. (PubMed, Carbohydr Polym)
    This review integrates the structural features and immunomodulatory mechanisms of algal β-glucans, aiming to assess their application potential across diverse fields. As research progresses, algal β-glucan is poised to play a significant role in therapeutic interventions, offering new insights into its potential in health promotion and disease prevention.
    Review • Journal
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    CLEC7A (C-Type Lectin Domain Containing 7A)
    24d
    Identification of multiple galectins as receptors for β-1,3-glucans. (PubMed, Carbohydr Polym)
    Additionally, β-1,3-glucan modulates galectin-mediated cell activation and apoptosis. Our findings not only expand the receptor repertoire of β-1,3-glucans and deepen our understanding of their immunomodulatory mechanisms, but they also indicate that galectins are promising therapeutic targets for regulating β-1,3-glucan-mediated immune responses, such as in anti-fungal therapy and cancer immunotherapy.
    Journal
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    CLEC7A (C-Type Lectin Domain Containing 7A) • MSR1 (Macrophage Scavenger Receptor 1)
    1m
    A tumor Microenvironment-Derived Prognostic Model Guides IL-27 as a Therapeutic Strategy to Restore T Cell Immunity in Lung Adenocarcinoma. (PubMed, Adv Biol (Weinh))
    Functionally, IL-27 blockade accelerated tumor growth, whereas recombinant IL-27 restrained tumor progression and enhanced PD-L1/CTLA-4 blockade efficacy by augmenting Th1 and cytotoxic T cell responses. These findings define a TME-based prognostic classifier and position IL-27 as a stage-dependent therapeutic target that restores T cell immunity and boosts checkpoint blockade efficacy.
    Journal
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CLEC7A (C-Type Lectin Domain Containing 7A) • CD200R1 (CD200 Receptor 1) • CD86 (CD86 Molecule) • CPLX2 (Complexin 2) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • S100P (S100 calcium binding protein P)
    1m
    A novel whole cancer cell vaccine based on modified β-glucan elicits robust anti-tumor immunity. (PubMed, Theranostics)
    G-PL, a novel β-glucan-based adjuvant, enables rapid construction of autologous whole-cell vaccines. This strategy enhances tumour-specific immunity and reprogrammes the tumour microenvironment, offering a universal platform for personalised cancer immunotherapy.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • CLEC7A (C-Type Lectin Domain Containing 7A)
    2ms
    Immune Microenvironment Signatures Predict Response and Survival in Rectal Cancer Patients After Neoadjuvant Chemoradiation. (PubMed, Anticancer Res)
    Immune-related gene expression patterns are associated with response to nCRT in rectal cancer. High expression levels of S100A8, SPINK5, ANXA1, FOXJ1, and CLEC7A were indicative of favorable treatment response, and S100A8 and SPINK5 were associated with prognosis. A machine learning-based model composed of immune-related genes showed strong predictive potential. Our results support the use of immune gene signatures to guide personalized therapy in rectal cancer.
    Journal
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    MUC1 (Mucin 1) • S100A8 (S100 Calcium Binding Protein A8) • ANXA1 (Annexin A1) • CCND3 (Cyclin D3) • TLR4 (Toll Like Receptor 4) • CLEC7A (C-Type Lectin Domain Containing 7A) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • CREB5 (CAMP Responsive Element Binding Protein 5) • DUSP4 (Dual Specificity Phosphatase 4) • TCF7 (Transcription Factor 7)
    2ms
    Differential Transcriptomic Features of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis with and Without Extrapulmonary Lesions in an East Asian Population. (PubMed, Biomedicines)
    These findings elucidate the mechanisms underlying granuloma formation in sarcoidosis and demonstrate the differential transcriptomic features of PBMCs in patients with and without EPL. The upregulation of IFNG and IFNLR1 may be related to EPL development and could serve as potential therapeutic targets for sarcoidosis.
    Journal
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    JAK2 (Janus kinase 2) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CLEC7A (C-Type Lectin Domain Containing 7A) • GBP5 (Guanylate Binding Protein 5) • IL17A (Interleukin 17A) • IL23A (Interleukin 23 Subunit Alpha) • MMP9 (Matrix metallopeptidase 9) • CD40LG (CD40 ligand) • IL15 (Interleukin 15) • IL1B (Interleukin 1, beta) • TNFRSF13C (TNF Receptor Superfamily Member 13C) • SOCS3 (Suppressor Of Cytokine Signaling 3)
    2ms
    Construction and validation of a lung adenocarcinoma prognostic model based on neutrophil extracellular traps and oxidative stress-related genes. (PubMed, Eur J Med Res)
    The constructed prognostic model by NETs and oxidative stress-relevant genes effectively predicts LUAD prognosis, correlates with immune microenvironment characteristics, and guides drug sensitivity, providing novel insights for LUAD prognostic assessment and personalized therapy.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • CD79A (CD79a Molecule) • CLEC7A (C-Type Lectin Domain Containing 7A) • EPHB2 (EPH Receptor B2) • ARHGEF3 (Rho Guanine Nucleotide Exchange Factor 3)
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    BI2536
    2ms
    Whole glucan particles enhance immune modulation in combination with TIGIT checkpoint blockade through Dectin-1 activation. (PubMed, Int J Biol Macromol)
    While the detailed signaling and apoptosis analyses were performed in LLC, the 4 T1 cohort reproduced the antitumor efficacy and immune-activation signatures, supporting generalizability. These results indicated that WGP augments TIGIT blockade through Dectin-1 mediated myeloid reprogramming and coordinated innate adaptive activation, and they supported β-glucan based innate priming as a rational partner for TIGIT and potentially other T-cell-directed checkpoint inhibitors.
    Journal • Checkpoint inhibition
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    CD8 (cluster of differentiation 8) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • IL10 (Interleukin 10) • SYK (Spleen tyrosine kinase) • TGFB1 (Transforming Growth Factor Beta 1) • CLEC7A (C-Type Lectin Domain Containing 7A)
    3ms
    Spatiotemporal profiling of endocytic regulators in the immunosuppressive TAM microenvironment of glioma. (PubMed, Brain Res)
    Immunohistochemistry and Western blot analyses further validated their elevated protein expression in high-grade glioma tissues. Collectively, this spatial multi-omic framework delineates endocytosis-associated immune remodeling in glioma and identifies FCGR2B, CLEC7A, and LYAR as potential biomarkers and therapeutic targets for disrupting immunosuppressive niches.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • CLEC7A (C-Type Lectin Domain Containing 7A) • FCGR2B (Fc Fragment Of IgG Receptor IIb)
    3ms
    Innate recognition and phagocytosis of zymosan by human neutrophils require cell priming in a p38-dependent manner. (PubMed, J Immunol)
    The results showed that priming occurs in a PKC- p38-dependent as well as a PKC-independent p38-dependent manner. The findings demonstrate a highly regulated innate immune mechanism that potentially rapidly tackles microbial pathogens invading the bloodstream and tissues.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CLEC7A (C-Type Lectin Domain Containing 7A)
    3ms
    The role of intratumoral microbiota in the occurrence and progression of tumors and its implications for guiding tumor treatment. (PubMed, Acta Microbiol Immunol Hung)
    Moreover, intratumoral microbiota can predict patient prognosis and guide personalized cancer treatment strategies, highlighting their potential as therapeutic targets. This review synthesizes current evidence on the roles of intratumoral microbiota across multiple cancer types and discusses their clinical implications.
    Review • Journal • IO biomarker
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    CLEC7A (C-Type Lectin Domain Containing 7A)