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    BIOMARKER:

    CLEC7A expression

    i
    Other names: CLEC7A, C-Type Lectin Domain Containing 7A, C-Type Lectin Domain Family 7 Member A, Dectin-1, C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12, C-Type Lectin Superfamily Member 12, DC-Associated C-Type Lectin 1, Beta-Glucan Receptor, CLECSF12, DECTIN1, SCARE2, CD369, BGR, Dendritic Cell-Associated C-Type Lectin-1, Dendritic Cell-Associated C-Type Lectin 1, C-Type Lectin Domain Family 7, Member A, Lectin-Like Receptor 1, CD369 Antigen, HDectin-1, CANDF4
    Entrez ID:
    64581
    Related biomarkers:
    Expression
    3ms
    Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade. (PubMed, bioRxiv)
    Increased tumoral cytotoxic T-lymphocyte densities and expanded CXCL13 + CD8 + T- cell populations were observed in responders, with increased tertiary lymphoid structures (TLSs) across all three patients. This study provides key insights into the mode of action of TLR8 agonism and anti-PD-1 blockade immune targeting in HNSCC patients.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • SYK (Spleen tyrosine kinase) • TLR8 (Toll Like Receptor 8) • CLEC7A (C-Type Lectin Domain Containing 7A)
    |
    CLEC7A expression
    over1year
    Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression. (PubMed, Nat Commun)
    Dectin-1 signaling upregulates PGE-synthesizing enzyme expression and PGE suppresses IL22RA2 expression in human CRC-infiltrating cells. These observations indicate a role of the Dectin-1-PGE-IL-22BP axis in regulating intestinal tumorigenesis, suggesting Dectin-1 as a potential target for CRC therapy.
    Journal
    |
    CLEC7A (C-Type Lectin Domain Containing 7A) • IL22 (Interleukin 22)
    |
    CLEC7A expression