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    BIOMARKER:

    CLDN18-ARHGAP fusion

    i
    Other names: CLDN18, Claudin-18, Surfactant, Pulmonary Associated Protein J, Surfactant Associated 5, SFTA5, SFTPJ, ARHGAP
    Entrez ID:
    51208
    Related biomarkers:
    Expression
    Fusion
    23d
    Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer. (PubMed, Gut)
    These results indicate that the CLDN18-ARHGAP26 fusion is a gain-of-function DGC oncogene that leads to activation of RHOA and activation of FAK and YAP signalling. These results argue for further evaluation of emerging FAK and YAP-TEAD inhibitors for these deadly cancers.
    Journal
    |
    TP53 (Tumor protein P53) • CLDN18 (Claudin 18) • RHOA (Ras homolog family member A) • COL1A1 (Collagen Type I Alpha 1 Chain)
    |
    CLDN18-ARHGAP fusion
    almost2years
    Immunotherapies for gastric cancer with CLDN18-ARHGAP fusion gene (ESMO 2022)
    Also, we revealed the role of CLDN18-ARHGAP fusion gene in promoting a suppressive TIME by facilitating the metabolism and proliferation of Tregs, which could be reversed by PI3Ki. Collectively, we demonstrated that CLDN18-ARHGAP is a potential target for immunotherapies in gastric cancer.
    IO biomarker
    |
    CLDN18 (Claudin 18) • IFNG (Interferon, gamma) • ARHGAP
    |
    CLDN18-ARHGAP fusion
    over2years
    Claudins and Gastric Cancer: An Overview. (PubMed, Cancers (Basel))
    Thus, CLDNs are highly expressed in GC as TJs and are expected targets for new antibody drugs. Herein, we review the literature on CLDNs, focusing on CLDN18 in GC.
    Review • Journal
    |
    CLDN18 (Claudin 18) • CLDN6 (Claudin 6) • ARHGAP • CLDN3 (Claudin 3)
    |
    CLDN18-ARHGAP fusion