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    GENE:

    CLASRP (CLK4 Associating Serine/Arginine Rich Protein)

    i
    Other names: CLASRP, CLK4 Associating Serine/Arginine Rich Protein, SWAP2, CLK4-Associating Serine/Arginine Rich Protein, SFRS16, CLASP, Splicing Factor, Arginine/Serine-Rich 16, Clk4 Associating SR-Related Protein, Splicing Factor, Arginine/Serine-Rich 16 (Suppressor-Of-White-Apricot Homolog, Drosophila), Suppressor Of White Apricot Homolog 2, Suppressor Of White-Apricot Homolog 2
    Associations

    News

    Trials
    over2years
    Long noncoding RNA LINC00482 silencing sensitizes non-small cell lung cancer cells to cisplatin by downregulating CLASRP via E2F1. (PubMed, Funct Integr Genomics)
    LINC00482 knockdown restricted tumor growth and enhanced DDP sensitivity in NSCLC in vivo. LINC00482 silencing downregulated CLASRP through E2F1 to facilitate the sensitivity to DDP in NSCLC.
    Journal
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    CLASRP (CLK4 Associating Serine/Arginine Rich Protein) • E2F1 (E2F transcription factor 1)
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    cisplatin
    over2years
    CLASRP oncogene as a novel target for colorectal cancer. (PubMed, Funct Integr Genomics)
    The expression levels of cleaved caspase 3 and cleaved caspase 8 were increased in CLASRP-overexpressing CRC cells treated with Clk inhibitors. CLASRP might serve as a promotional oncogene in CRC cells and be suppressed by Clk inhibitors through activation of caspase pathways.
    Journal
    |
    CASP3 (Caspase 3) • CASP8 (Caspase 8) • CLASRP (CLK4 Associating Serine/Arginine Rich Protein)