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    GENE:

    CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)

    i
    Other names: CKS2, CDC28 Protein Kinase Regulatory Subunit 2, Cyclin-Dependent Kinases Regulatory Subunit 2, CDC28 Protein Kinase 2, CKS-2, CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-2, CKSHS2
    Associations

    News

    Trials
    24d
    Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)
    In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    2ms
    Uncovering functional divergence and cellular clusters with specific gene signatures in HNSCC clonal spheroids. (PubMed, Cell Commun Signal)
    Hyperproliferative spheroids (HRPS) showed increased proliferation and tumorigenic potential, whereas hypoproliferative spheroids (HOPS) demonstrated enhanced migration and resistance to cisplatin and radiation...Notably, the gene expression profiles of Cluster 3 in the HOPS and Cluster 1 in the HRPS closely matched the expression patterns observed in the HNSCC-TCGA dataset. These clusters also displayed a high transcriptional correlation between patient tumors and their xenografts, reinforcing the clonal nature of HNSCC's genetic and functional diversity of HNSCC.
    Journal • Gene Signature
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    TOP2A (DNA topoisomerase 2-alpha) • AURKA (Aurora kinase A) • ALDH3A1 (Aldehyde Dehydrogenase 3 Family Member A1) • ANLN (Anillin Actin Binding Protein) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
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    cisplatin
    3ms
    Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma. (PubMed, Transl Oncol)
    In vitro experiments, the combination of elesclomol (a copper ion carrier) and bortezomib (Bortezomib) demonstrated a synergistic anti-myeloma effect through excessive intracellular reactive oxygen species generation. This study provides valuable insights into the role of CRGs in MM, potentially aiding in prognosis prediction and the development of effective, personalized therapeutic strategies.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • DLAT (Dihydrolipoamide S-Acetyltransferase) • MELTF (Melanotransferrin) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • PDHA1 (Pyruvate Dehydrogenase E1 Subunit Alpha 1)
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    bortezomib • elesclomol (STA-4783)
    4ms
    CKS2 promotes the malignant phenotypes of bladder cancer cells via PI3K/AKT signaling pathway activation. (PubMed, Cell Cycle)
    Notably, treatment with the PI3K inhibitor LY294002 effectively reversed CKS2-induced BC cell proliferation and metastasis. In conclusion, CKS2 promoted the malignant phenotypes of BC cells by enhancing PI3K/AKT pathway activity through dual mechanisms involving PTEN downregulation and p27 Kip1-mediated cell cycle dysregulation.
    Journal
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    PTEN (Phosphatase and tensin homolog) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
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    LY294002
    4ms
    Synergistic dual oncogenic role of CKS2 and ACAT2: Enhanced regulatory coherence and biomarker potential in adrenocortical carcinoma. (PubMed, Cancer Genet)
    Together, these roles support a synergistic oncogenic axis in which proliferative acceleration is metabolically sustained, reinforcing tumor growth. These findings nominate CKS2 and ACAT2 as robust biomarkers and mechanistic drivers with translational relevance in ACC.
    Journal
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    CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
    4ms
    m6A-mediated upregulation of miR-3690 drives HNSCC progression by regulating nuclear-cytoplasmic signaling pathway. (PubMed, Cell Mol Life Sci)
    Finally, methylated RNA Immunoprecipitation (meRIP) and RNA pull down indicated that METTL3 and METTL14-mediated m6A modification accelerated pri-miR-3690 maturation through regulating the processing of pri-miR-3690 by DGCR8. In conclusion, miR-3690 may be a prognostic indicator and potential therapeutic target for HNSCC.
    Journal
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    CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • METTL14 (Methyltransferase 14) • METTL3 (Methyltransferase Like 3)
    5ms
    CKS2 is overexpressed in high-grade and recurrent meningiomas and functions as an oncogene via the CKS2/miR-26a/miR-101 axis. (PubMed, Comput Biol Med)
    Further, epigenetic regulation of CKS2 via downregulated microRNAs-miR-26a-5p and miR-101-3p, and their tumor-suppressive effects in meningioma were elucidated. In summary, we identify the CKS2/miR-26a/miR-101 axis as a key regulatory axis in advanced grade meningiomas with therapeutic potential and highlight CKS2 as a promising diagnostic and prognostic marker.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • CCNB2 (Cyclin B2) • CDK1 (Cyclin-dependent kinase 1) • GSTM1 (Glutathione S-transferase mu 1) • KIF11 (Kinesin Family Member 11) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • CCNB1 (Cyclin B1) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • KIF20A (Kinesin Family Member 20A) • MIR26A1 (MicroRNA 26a-1)
    5ms
    Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: an in silico study utilising molecular docking and dynamics simulation. (PubMed, Front Bioinform)
    Digoxin (DB00390) has been highlighted as a potential repurposed drug candidate because of its favorable drug-likeness and stability, as confirmed by virtual screening, ADMET analysis, molecular docking study and dynamic simulations...It presents several promising biomarkers for the early diagnosis, prognosis, and therapy. Further investigation into CDK1/CKS2 as a therapeutic target and the role of the identified biomarkers could contribute to improved diagnostic and therapeutic strategies for HCC.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
    5ms
    Curcumin as an Epigenetic Modulator: Suppression of Breast Cancer via the Hsa_circ_0001946/MiR-7-5p/Target Gene Axis. (PubMed, Medicina (Kaunas))
    This preliminary study shows that curcumin suppresses BC tumorigenesis by modulating the hsa_circ_0001946/miR-7-5p/target gene axis. While these findings suggest a novel regulatory pathway and potential therapeutic targets, further in vivo validation and clinical trials are required to determine the translational relevance of curcumin in BC therapy.
    Journal • PARP Biomarker
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    TOP2A (DNA topoisomerase 2-alpha) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • MIR7 (MicroRNA 7) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
    5ms
    Facilitation of natural killer T-cell cytotoxic activity in uterine sarcoma via the CKS2-PI3K-AKT-MICA axis. (PubMed, Transl Cancer Res)
    Mechanistically, CKS2 activated the PI3K/AKT signaling, reduced major histocompatibility complex (MHC) class I chain-related protein A (MICA) expression, and inhibited NKT cell activity, resulting in immune escape, which was effectively mitigated by PI3K inhibitors. The findings suggest that CKS2 can serve as a valuable biomarker and an effective target for the prevention and screening of uterine sarcoma and can modify the antitumor immune response in uterine sarcoma.
    Journal
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    MICA (MHC Class I Polypeptide-Related Sequence A) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
    6ms
    CKS2 Mediates Hepatocellular Carcinoma Recurrence After Hepatic Ischemia-Reperfusion Injury Related to M2 Macrophages. (PubMed, J Inflamm Res)
    Ultimately, the expression pattern of CKS2 and its correlation with M2 macrophages in HCC were confirmed through experimental validation. CKS2 was identified as a key factor in HIRI-induced HCC recurrence and was critically associated with M2 macrophage infiltration abundance, providing novel insights and a direction for future research.
    Journal
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    CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)
    7ms
    Nuclear Transport Receptor Importin-β Inhibition Enhances Cell Cycle Arrest Induced by CKS2 Knockdown to Suppress Neuroblastoma Progression. (PubMed, Neurochem Res)
    These findings demonstrate that CKS2 promotes neuroblastoma progression by facilitating cell division via the CDK1/Cyclin B1 complex. Targeting CKS2, especially in combination with nuclear import inhibition, offers a promising therapeutic strategy for neuroblastoma.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2)