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    BIOMARKER:

    CIITA rs4774

    i
    Other names: CIITA, Class II Major Histocompatibility Complex Transactivator, MHC Class II Transactivator, MHC2TA, C2TA, NLRA, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Acid Domain Containing, NLR Family, Acid Domain Containing, Class II, Major Histocompatibility Complex, Transactivator, MHC Class II Transactivator Type III, MHC Class II Transactivator Type I, CIITAIV
    Entrez ID:
    4261
    almost3years
    Single nucleotide polymorphisms (SNPs) in MHC class I and II genes to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3, MAVERICC, and TRIBE trials. (ASCO 2023)
    Genomic DNA from blood samples of 775 pts enrolled in three independent, randomized, first-line trials: TRIBE (FOLFIRI-bevacizumab [bev], N = 215), FIRE-3 (FOLFIRI-bev, N = 107; FOLFIRI-cetuximab [cet], N = 129) and MAVERICC (FOLFIRI-bev, N = 163; FOLFOX-bev, N = 161) was genotyped through OncoArray, a custom array manufactured by Illumina including approximately 530K SNP markers... Our results highlight an important role for MHC SNPs as prognostic and predictive biomarkers for first-line treatment in mCRC, with differential effects based on biologic agent and chemotherapy backbone. These biomarkers, when further validated, may contribute to personalized treatment strategies for mCRC patients.
    Clinical • Metastases
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    B2M (Beta-2-microglobulin) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1) • HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) • HLA-E (Major Histocompatibility Complex, Class I, E) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • TAP1 (Transporter 1) • HLA-C (Major Histocompatibility Complex, Class I, C)
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    CIITA rs4774 • ERAP1 rs26653 • HLA-B rs2770 • HLA-DMB rs10751 • HLA-DOB rs11244 • HLA-DPB1 rs3097671 • HLA-DRA rs7192 • HLA-G rs1610696 • TAP1 rs1135216 • TAP2 rs1044043 • TAP2 rs1800454 • TAPBP rs3106191 • TAP2 rs241447
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    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan • leucovorin calcium