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BIOMARKER:

CIC deletion

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Other names: CIC, Capicua Transcriptional Repressor, Protein Capicua Homolog, Capicua (Drosophila) Homolog, Capicua Homolog (Drosophila), KIAA0306, MRD45
Entrez ID:
Related biomarkers:
5ms
Loss of Capicua impairs oligodendrogenesis in the developing mouse brain (SNO 2023)
We showed that OPC-specific Cic knockout results in increased cellular proliferation and maturation defects in the developing mouse brain. Cic loss may contribute to ODG formation by promoting developmental programs and inhibiting oligodendrocyte maturation in postnatal OPCs.
Preclinical
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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CIC deletion
12ms
New P1 trial
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NF1 (Neurofibromin 1)
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NF1 mutation • CIC deletion • CIC mutation
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ulixertinib (BVD-523)
over1year
The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression. (PubMed, Elife)
Targeting ETV1 in CIC and ERF-deficient prostate cancer limits tumor growth. Thus, we have uncovered a fusion-independent mode of ETS transcriptional activation defined by concurrent loss of CIC and ERF.
Journal
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ETV1 (ETS Variant Transcription Factor 1)
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CIC deletion
almost4years
CIC is a critical regulator of neuronal differentiation. (PubMed, JCI Insight)
Mass spectrometry analysis of CIC-interacting proteins further identified BRG1 containing mSWI/SNF complex whose function is necessary for transcriptional repression by CIC. Together, this study uncovers a novel regulatory pathway of CIC-dependent neuronal differentiation and may implicate these molecular mechanisms in CIC-dependent brain tumorigenesis.
Journal
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SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4)
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CIC deletion