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    BIOMARKER:

    CIC deletion

    i
    Other names: CIC, Capicua Transcriptional Repressor, Protein Capicua Homolog, Capicua (Drosophila) Homolog, Capicua Homolog (Drosophila), KIAA0306, MRD45
    Entrez ID:
    23152
    Related biomarkers:
    Mutation
    2years
    CIC is a critical regulator of neuronal differentiation. (PubMed, JCI Insight)
    Mass spectrometry analysis of CIC-interacting proteins further identified BRG1 containing mSWI/SNF complex whose function is necessary for transcriptional repression by CIC. Together, this study uncovers a novel regulatory pathway of CIC-dependent neuronal differentiation and may implicate these molecular mechanisms in CIC-dependent brain tumorigenesis.
    Journal
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    SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4)
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    CIC deletion