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BIOMARKER:

CIC deletion

i
Other names: CIC, Capicua Transcriptional Repressor, Protein Capicua Homolog, Capicua (Drosophila) Homolog, Capicua Homolog (Drosophila), KIAA0306, MRD45
Entrez ID:
Related biomarkers:
2years
CIC is a critical regulator of neuronal differentiation. (PubMed, JCI Insight)
Mass spectrometry analysis of CIC-interacting proteins further identified BRG1 containing mSWI/SNF complex whose function is necessary for transcriptional repression by CIC. Together, this study uncovers a novel regulatory pathway of CIC-dependent neuronal differentiation and may implicate these molecular mechanisms in CIC-dependent brain tumorigenesis.
Journal
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SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4)
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CIC deletion