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    BIOMARKER:

    CHRNA6 overexpression

    i
    Other names: CHRNA6, Cholinergic Receptor Nicotinic Alpha 6 Subunit, Acetylcholine Receptor, Nicotinic, Alpha 6 (Neuronal), Cholinergic Receptor, Nicotinic, Alpha Polypeptide 6, Cholinergic Receptor, Nicotinic, Alpha 6 (Neuronal), Neuronal Acetylcholine Receptor Subunit Alpha-6, Cholinergic Receptor, Nicotinic Alpha 6, CHNRA6
    Entrez ID:
    8973
    almost2years
    CHRNA6 RNA in situ hybridization is a useful tool for the diagnosis of extraskeletal myxoid chondrosarcoma. (PubMed, Mod Pathol)
    All examined cases of histological mimics were negative for CHRNA6 overexpression; however, limited CHRNA6 expression, not reaching a threshold of greater than 5 puncta or one aggregate of chromogen in more than 25% of cells, was observed in 69 of 685 mimics (10.1%), spanning an array of mesenchymal tumors. Taken together, these findings suggest that, with careful interpretation and the use of appropriate thresholds, CHRNA6 RNA CISH is a potentially useful ancillary histological tool for the diagnosis of EMC.
    Journal
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    EWSR1 (EWS RNA Binding Protein 1) • NR4A3 (Nuclear receptor subfamily 4 group A member 3) • TAF15 (TATA-Box Binding Protein Associated Factor 15) • CHRNA6 (Cholinergic Receptor Nicotinic Alpha 6 Subunit) • SYP (Synaptophysin) • TCF12 (Transcription Factor 12)
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    CHRNA6 overexpression
    2years
    Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease. (PubMed, Curr Pharm Des)
    CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.
    Journal • IO biomarker
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    CHRNA6 (Cholinergic Receptor Nicotinic Alpha 6 Subunit)
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    CHRNA6 overexpression
    |
    adavosertib (AZD1775)