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    BIOMARKER:

    CHRM3 overexpression

    i
    Other names: CHRM3, Cholinergic Receptor Muscarinic 3, Acetylcholine Receptor, Muscarinic 3, Muscarinic Acetylcholine Receptor M3, M3 Muscarinic Receptor, EGBRS, HM3, PBS
    Entrez ID:
    1131
    almost3years
    MiR-15b-5p inhibits castration-resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor CHRM3. (PubMed, FEBS Lett)
    Furthermore, miR-15b-5p abolished the growth of CRPC cells induced by CHRM3 stimulation. We conclude that the miR-15b-5p/CHRM3/YAP signalling axis promotes the castration-resistant growth of prostate cancer.
    Journal
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    CHRM3 (Cholinergic Receptor Muscarinic 3) • MIR15B (MicroRNA 15b)
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    CHRM3 overexpression
    4years
    Mechanistic Clues Provided by Concurrent Changes in the Expression of Genes Encoding the M Muscarinic Receptor, β-Catenin Signaling Proteins, and Downstream Targets in Adenocarcinomas of the Colon. (PubMed, Front Physiol)
    CHRM1 expression levels were positively associated with those for APC and SMAD4, and negatively associated with CTNNB1, the gene for β-catenin, and with coordinate changes in the expression of β-catenin target genes. These findings implicating CHRM1/MR as an important deterrent of colon cancer development and progression warrant further exploration.
    Journal
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    SMAD4 (SMAD family member 4) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CHRM3 (Cholinergic Receptor Muscarinic 3)
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    CHRM3 overexpression