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    BIOMARKER:

    Chr t(4;9;22)(q21;q34;q11.2)

    over4years
    A unique three-way Philadelphia chromosome variant t(4;9;22)(q21;q34;q11.2) in a newly diagnosed patient with chronic phase chronic myeloid leukemia: a case report and review of the literature. (PubMed, J Med Case Rep)
    This was the 14th case of t(4;9;22), in particular, a new variant Ph translocation involved in chromosome 4q21 and the first successful case treated with tyrosine kinase inhibitors in the world. We summarize previous case reports regarding three-way variant chromosome translocation, t(4;9;22) and discuss how this rare translocation is linked to prognosis.
    Clinical • Review • Journal
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    ABL1 (ABL proto-oncogene 1)
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    Chr t(4;9;22)(q21;q34;q11.2)
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    dasatinib • bosutinib