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CHM 2301
i
Other names: CHM 2301, CDH17 CAR-NK
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Company:
Case Western Reserve University, Chimeric Therap
Drug class:
NK cell stimulant, CDH17 inhibitor
Related drugs:
over1year
Development of allogenic nonviral RNA-based CAR-NK therapy targeting CDH17 in relapsed/refractory gastrointestinal cancer. (ASCO 2023)
Ex vivo expanded human peripheral blood NK (Magicell-NK, Medigen, Taiwan) cells were used in this study. Our findings suggest that a non-viral based CDH17 CAR-NK cell therapy could be a potential allogeneic, off-the-shelf CAR-NK therapy candidate in GI cancer and support the rationale of further investigating it in vivo and clinical trials.
IO biomarker
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TNFA (Tumor Necrosis Factor-Alpha) • LAMP1 (Lysosomal Associated Membrane Protein 1) • CDH17 (Cadherin 17)
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CDH17 CAR-NK cell therapy • CHM 2301 • Magicell-NK
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