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    GENE:

    CHID1 (Chitinase Domain Containing 1)

    i
    Other names: CHID1, Chitinase Domain Containing 1, SI-CLP, Stabilin-1 Interacting Chitinase-Like Protein, Chitinase Domain-Containing Protein 1, Stabilin-1-Interacting Chitinase-Like Protein, FLJ42707, MGC3234, GL008, SICLP, CHID1
    over2years
    Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes. (PubMed, Open Res Eur)
    Ergolide is a novel, promising anti-proliferative agent for UM/MUM. Proteomic profiling of OMM2.5 cellular/EV lysates identified candidate pathways elucidating the action of ergolide and putative biomarkers of UM, that require further examination.
    Journal • BRCA Biomarker • Metastases
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    BRCA2 (Breast cancer 2, early onset) • GDF15 (Growth differentiation factor 15) • HMOX1 (Heme Oxygenase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CHID1 (Chitinase Domain Containing 1)
    over3years
    Chitinase domain containing 1 increase is associated with low survival rate and M0 macrophages infiltrates in colorectal cancer patients. (PubMed, Pathol Res Pract)
    Mirror results were obtained for the GSNC-CHID1 signature. From the outcome of our investigation, it is possible to conclude that HCEL are associated with an unfavorable prognosis for CRC patients.
    Journal
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    BRAF (B-raf proto-oncogene) • CHID1 (Chitinase Domain Containing 1)
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    BRAF mutation
    almost5years
    CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer. (PubMed, Int J Mol Sci)
    We suggest that in the case of lung cancer, tumor-associated macrophages are likely ineffective as a therapeutic target. At the same time, macrophage markers expressed by tumor cells may be considered as targets for anti-tumor therapy or, as in the case of CHID1, as potential anti-tumor agents.
    Journal
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    CD163 (CD163 Molecule) • CHID1 (Chitinase Domain Containing 1)