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    GENE:

    CHD6 (Chromodomain Helicase DNA Binding Protein 6)

    i
    Other names: CHD6, Chromodomain Helicase DNA Binding Protein 6, CHD5, RIGB, KIAA1335, Chromodomain-Helicase-DNA-Binding Protein 6, Radiation-Induced Gene B Protein, ATP-Dependent Helicase CHD6, DJ620E11.1, FLJ22369, CHD-6, Helicase C-Terminal Domain- And SNF2 N-Terminal Domain-Containing Protein
    Associations

    News

    Trials
    11ms
    CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair. (PubMed, Nat Commun)
    DNA repair pathway screening reveals that CHD6 loss elicits insufficiency in apurinic-apyrimidinic endonuclease (APEX1) activity and genomic abasic site accumulation. We reveal APEX1-linked roles for CHD6 important for understanding PARP1/2-trapping inhibitor sensitivity.
    Journal
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • RAD51 (RAD51 Homolog A) • APEX1 (Apurinic/Apyrimidinic Endodeoxyribonuclease 1) • CHD6 (Chromodomain Helicase DNA Binding Protein 6)
    12ms
    CHD6 eviction of promoter nucleosomes maintains housekeeping transcriptional program in prostate cancer. (PubMed, Mol Ther Nucleic Acids)
    Furthermore, this regulatory model also exists in both HEK293 cells and cardiomyocytes. Overall, the results of this study demonstrate that CHD6 binds to the promoter regions of housekeeping genes, regulating their histone modifications, chromatin structure, and gene expression.
    Journal
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    GOLGA5 (Golgin A5) • CHD6 (Chromodomain Helicase DNA Binding Protein 6)
    1year
    Chromatin Helicase CHD6 Establishes Pro-inflammatory Enhancers and is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma. (PubMed, Cancer Res)
    The PROTAC degrader of SMARCA2/4 AU-15330 effectively abolished structures of cis-regulatory elements bound by CHD6 and suppressed the growth of FH-mutated, but not FH-intact, RCC in vivo. Collectively, these data indicate that CHD6 is a molecular bridge between FH deficiency and pro-inflammatory enhancers assembly that endows FH-deficient tumors with epigenetic vulnerabilities.
    Journal • Synthetic lethality
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    KEAP1 (Kelch Like ECH Associated Protein 1) • FH (Fumarate Hydratase) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) • CHD6 (Chromodomain Helicase DNA Binding Protein 6)
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    AU-15330
    over2years
    Racial and sex differences in tumor genomics in urothelial carcinoma. (PubMed, Urol Oncol)
    These differences highlight the importance of enriching cohorts for female and non-White patients in genomic studies and clinical trials, especially as we test the use of molecular biomarkers to personalize care for patients with bladder cancer.
    Journal
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    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • HRAS (Harvey rat sarcoma viral oncogene homolog) • ARID1A (AT-rich interaction domain 1A) • EP300 (E1A binding protein p300) • NCOR1 (Nuclear Receptor Corepressor 1) • CHD6 (Chromodomain Helicase DNA Binding Protein 6)
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    TP53 mutation • PIK3CA mutation • ARID1A mutation • HRAS mutation • EP300 mutation