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    GENE:

    CFAP58 (Cilia And Flagella Associated Protein 58)

    i
    Other names: CFAP58, Cilia And Flagella Associated Protein 58, Cilia- And Flagella-Associated Protein 58, Coiled-Coil Domain-Containing Protein 147, Coiled-Coil Domain Containing 147, BA554P13.1, C10orf80, CCDC147, Chromosome 10 Open Reading Frame 80, BA127L20.4, BA127L20.5, FLJ35908, SPGF49
    9ms
    Identification of an Anoikis-associated LncRNA Signature to Predict the Clinical Prognosis and Immune Function of Patients with Endometrial Cancer. (PubMed, Int J Med Sci)
    The signature constructed using these lncRNAs may offer new avenues for endometrial cancer treatment and immunotherapy. The function of CFAP58-DT has been validated in vitro and in vivo, consistent with our previous analysis; however, further research into its upstream and downstream mechanisms is warranted.
    Journal • IO biomarker
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    CFAP58 (Cilia And Flagella Associated Protein 58)
    10ms
    Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes. (PubMed, J Pathol)
    © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
    Journal
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    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • FGFR3 (Fibroblast growth factor receptor 3) • EML4 (EMAP Like 4) • FGFR1 (Fibroblast growth factor receptor 1) • HRAS (Harvey rat sarcoma viral oncogene homolog) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • STRN (Striatin) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • CFAP58 (Cilia And Flagella Associated Protein 58)
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    KRAS mutation • EGFR mutation • BRAF mutation • NRAS mutation • FGFR2 mutation • KRAS wild-type • FGFR2 fusion • ALK fusion • ALK mutation • RAS wild-type • HRAS mutation • AKT1 mutation
    over1year
    Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications. (PubMed, Geroscience)
    The CFAP58 carriers were at elevated risk of deaths due to cancers. Collectively, the present whole exome sequencing study provides novel insights into the genetic landscape of LTL, identifying novel genes associated with LTL and their implications on human health and facilitating a better understanding of aging, thus pinpointing the genetic relevance of LTL with clonal hematopoiesis, biomedical traits, and health-related outcomes.
    Journal
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    ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • CFAP58 (Cilia And Flagella Associated Protein 58)
    almost3years
    Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer. (PubMed, Ann Transl Med)
    Overall, we identified a prognostic ferroptosis-related lncRNA model based on CFAP58-DT for predicting the prognosis and immune-infiltrating conditions in EC. We concluded that the potential oncogenic role of CFAP58-DT can further guide immunotherapy and chemotherapy.
    Journal • IO biomarker
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    CFAP58 (Cilia And Flagella Associated Protein 58)
    over3years
    The IFN-γ-related long non-coding RNA signature predicts prognosis and indicates immune microenvironment infiltration in uterine corpus endometrial carcinoma. (PubMed, Front Oncol)
    In the immunological microenvironment, there were also substantial disparities across different risk categories. Our findings give a reference for endometrial cancer prognostic type and immunological status assessment, as well as prospective molecular markers for the disease.
    Journal
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    IFNG (Interferon, gamma) • CFAP58 (Cilia And Flagella Associated Protein 58)
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    IFNG expression
    over3years
    Ferroptosis-Related lncRNA for the Establishment of Novel Prognostic Signature and Therapeutic Response Prediction to Endometrial Carcinoma. (PubMed, Biomed Res Int)
    In addition, the nine FRLs were all more expressed in the high-risk group compared to the low-risk group. These findings significantly contribute to the understanding of the function of FRLs in UCEC and provide promising therapeutic strategies for UCEC.
    Journal • IO biomarker
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    CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CD40 (CD40 Molecule) • CFAP58 (Cilia And Flagella Associated Protein 58)
    over4years
    Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer. (PubMed, Breast Cancer Res Treat)
    Neoadjuvant docetaxel and carboplatin resulted in a pCR of 45.7%. WES and immune profiling differentiated patients with and without pCR.
    Clinical • Journal • Tumor Mutational Burden • PD(L)-1 Biomarker • IO biomarker
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    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • RB1 (RB Transcriptional Corepressor 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • PD-L2 (Programmed Cell Death 1 Ligand 2) • RAD51 (RAD51 Homolog A) • IDO1 (Indoleamine 2,3-dioxygenase 1) • COL4A5 (Collagen Type IV Alpha 5 Chain) • CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S) • CFAP58 (Cilia And Flagella Associated Protein 58) • COL22A1 (Collagen Type XXII Alpha 1 Chain) • KPRP (Keratinocyte Proline Rich Protein) • L1CAM (L1 cell adhesion molecule) • PCDHA1 (Protocadherin Alpha 1) • SDK2 (Sidekick Cell Adhesion Molecule 2)
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    EGFR mutation • TMB-H • COL4A5 mutation • PCDHA1 mutation • RAD51 mutation
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    carboplatin • docetaxel